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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Prevention of cardiogenic arterial thromboembolism (ATE) in heart disease; improves pelvic-limb circulation post-embolism (serotonin-release inhibition)
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Prevention of cardiogenic arterial thromboembolism (ATE) in heart disease; improves pelvic-limb circulation post-embolism (serotonin-release inhibition) — Extra-label (human drug)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Hypercoagulable states; thromboembolism prevention (e.g., heartworm-associated embolism, IMHA adjunct)
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Hypercoagulable states; thromboembolism prevention (e.g., heartworm-associated embolism, IMHA adjunct) — Extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens5
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects203
Vomiting, anorexia — Main veterinary effect — give with food
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Bleeding (major bleeding ~2% human pre-clinical rate) — Dose-related; higher with aspirin combo
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Rare: TTP (<2 weeks onset), rash, diarrhea — Human reports
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Immune mediated haemolytic anaemia30 reports
- Death by euthanasia29 reports
- Diarrhoea24 reports
- Lethargy (see also Central nervous system depression in 'Neurological')23 reports
- Elevated blood urea nitrogen (BUN)22 reports
- Vomiting21 reports
- Elevated total bilirubin20 reports
- Lethargy (see also Central nervous system depression in Neurological)19 reports
- Anorexia18 reports
- Leucocytosis NOS18 reports
- Anaemia NOS17 reports
- Not eating17 reports
Cat
- Vomiting24 reports
- Death by euthanasia22 reports
- Lethargy (see also Central nervous system depression in Neurological)16 reports
- Weight loss16 reports
- Anorexia12 reports
- Death10 reports
- Diarrhoea9 reports
- Increased respiratory rate9 reports
- Lack of efficacy - NOS8 reports
- Decreased appetite7 reports
- Ataxia6 reports
- Congestive heart failure6 reports
Monitoring1
Bleeding signs (melena, petechiae, prolonged bleeding); efficacy not routinely measurable in practice
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Active pathologic bleeding; hypersensitivity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions5
Stop ~1 week pre-surgery if possible; limited clinical experience in cats overall
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Clopidogrel > aspirin for feline ATE prevention (superior platelet inhibition; different mechanism — ADP receptor vs COX-1). The related ticlopidine must NOT be used in cats (adverse reactions).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Irreversible platelet binding → effect outlasts the drug: plan peri-operative discontinuation ~5–7 days ahead.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
In cats it also inhibits platelet serotonin release — rationale for use after a cardiogenic embolic event to improve collateral circulation.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
¼ tablet daily of the human 75 mg product is the practical feline regimen; clinical efficacy trials remain limited (dosing largely extrapolated).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions5
Aspirin — ↑ bleeding risk (but commonly combined deliberately)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
NSAIDs, warfarin — ↑ bleeding risk; metabolism interference
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Proton pump inhibitors (omeprazole) — May ↓ clopidogrel efficacy (CYP-mediated activation competition) — significance debated
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Heparins — Appears safe combined
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Phenytoin, torsemide — Metabolism interference (human data)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics4
Activation — Hepatic pro-drug → unstable active metabolite (irreversible ADP-receptor binding)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Onset/offset — Max effect ~3 days; platelet function normal ~7 days after stopping (cats)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life (human) — Active fraction bound to platelets ~11 days; inactive metabolites renally/fecally excreted
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Bioavailability — ~50% (human), food-insensitive
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Human FDA category B (no teratogenicity at 65–78× human dose in rats/rabbits). Distributed into rat milk — weigh risk; milk replacer if concerned.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 302–304; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 176–177 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references16
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Efficacy of dual therapy with rivaroxaban and clopidogrel in canine aortic thrombosis resistant to clopidogrel monotherapy: two case reports.
Study summary not available in the imported record. Open the original citation to review the study.
- Treatment and Prevention of Cardiogenic Arterial Thromboembolism in the Cat: A Systematic Review.
Study summary not available in the imported record. Open the original citation to review the study.
- Evaluation of clopidogrel responsiveness using the Platelet Function Analyzer-200 (PFA-200) in dogs.
Study summary not available in the imported record. Open the original citation to review the study.
- Evaluation of clopidogrel impact on canine platelet function using flow cytometry and thromboelastography platelet mapping.
Study summary not available in the imported record. Open the original citation to review the study.
- Suspected clopidogrel-associated hepatitis in a cat.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.