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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications3
Non-infectious degenerative/traumatic arthritis (label — the "disease-modifying" injectable)
DogOn-label (ON_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Non-infectious degenerative/traumatic arthritis (label — the "disease-modifying" injectable) — Authorized (Adequan Canine)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Non-infectious/traumatic joint dysfunction + carpal lameness (label)
HorseOn-label (ON_LABEL)1 source record · View provenance
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Non-infectious/traumatic joint dysfunction + carpal lameness (label) — Authorized (Adequan IM/IA)
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Chondroprotection (anecdotal tier)
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Chondroprotection (anecdotal tier) — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens4
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects72
IM route: adverse effects unlikely — The clean-route reputation
DogHorseNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Post-IA-injection inflammation (pain/effusion/lameness — sensitivity, technique, frequency) — IA-route risk
HorseNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Joint sepsis after IA injection — The catastrophic-if-sloppy risk — asepsis is the rule
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Dose-related coagulation inhibition (dogs) — Bleeding tendency described
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Increased bleeding post-arthrotomy (unconfirmed) — Timing caution
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Abnormal radiograph finding2 reports
- Bone and joint disorder NOS2 reports
- Death by euthanasia2 reports
- Lack of efficacy - NOS2 reports
- Panting2 reports
- Vestibular disorder NOS2 reports
- Abdominal mass1 reports
- Anorexia1 reports
- Anxiety1 reports
- Ataxia1 reports
- Barking1 reports
- Behavioural disorder NOS1 reports
Cat
- Hyperpigmentation1 reports
- Immediate pain upon injection1 reports
- Pruritus1 reports
- Skin scab1 reports
- Vocalisation1 reports
Monitoring1
Lameness/functional scores across the series; injection technique (IA); bleeding signs (dogs)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Hypersensitivity (IA); not a substitute for infection treatment, surgery, or immobilization where indicated
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Don't use within 1 wk of arthrotomy (dog — unconfirmed bleeding concern); coagulopathy watch
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The IM route that acts IN the joint: articular levels beating serum after IM dosing is the Adequan PK legend — injection series without needle-in-joint risk.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The IA trade: faster local effect but post-injection flare + sepsis stakes — hence the amikacin-125 companion habit in equine practice.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
"Disease-modifying" in the label sense: proteoglycan preservation + enzyme inhibition vs the symptomatic-only tier (NSAIDs) — the OA-treatment ladder teaching point.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions2
Anticoagulants (dog coagulation effect) — Theoretical additive
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Amikacin 125 mg (deliberate IA companion) — Sepsis prophylaxis per sources
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics2
Mechanism — Proteolytic-enzyme inhibition in cartilage + proteoglycan-precursor + ↑synovial hyaluronate + ↓PGE2 — the multi-mechanism "disease-modifying" claim
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Joint targeting — IM dosing → articular levels EXCEED serum (preferential osteoarthritic-cartilage uptake); joint peak 48 h, persist 96 h
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Label breeding-safety statements; class generally permissible.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 986–988 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references20
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Anecdotal or experimental: how does published safety evidence affect self-reported willingness of avian veterinarians to use certain drugs in clinical practice?
Study summary not available in the imported record. Open the original citation to review the study.
- Hemorrhagic diathesis in avian species following intramuscular administration of polysulfated glycosaminoglycan.
Study summary not available in the imported record. Open the original citation to review the study.
- Oversulfated chondroitin sulfate inhibits the complement classical pathway by potentiating C1 inhibitor.
Study summary not available in the imported record. Open the original citation to review the study.
- Effects of extracorporeal shock wave therapy and polysulfated glycosaminoglycan treatment on subchondral bone, serum biomarkers, and synovial fluid biomarkers in horses with induced osteoarthritis.
Study summary not available in the imported record. Open the original citation to review the study.
- Efficacy of intramuscular polysulfated glycosaminoglycan in a controlled study of equine carpitis.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.