Favorites and recent references stay on this device. No patient data is stored.
Choose the species
One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Dermatophytosis, Malassezia dermatitis (adjunct), nasal aspergillosis (adjunct with topical therapy)
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Dermatophytosis, Malassezia dermatitis (adjunct), nasal aspergillosis (adjunct with topical therapy) — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Dermatophytosis, Malassezia dermatitis (adjunct), nasal aspergillosis (adjunct with topical therapy) — Extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens4
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects206
Vomiting, inappetence, diarrhea — Most common
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
↑ Liver enzymes — Possible, more with continuous high-dose vs. pulse dosing
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Facial pruritus — Reported
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Lethargy — Case report
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Lack of efficacy - NOS1,930 reports
- Vomiting563 reports
- Ear discharge455 reports
- Ataxia438 reports
- Head tilt - ear disorder435 reports
- Head shake - ear disorder383 reports
- Corneal ulcer353 reports
- Deafness346 reports
- Lethargy (see also Central nervous system depression in 'Neurological')344 reports
- Behavioural disorder NOS315 reports
- Nystagmus313 reports
- Loss of hearing264 reports
Cat
- Ataxia356 reports
- Horner's syndrome242 reports
- Anorexia187 reports
- Third eyelid protrusion165 reports
- Head tilt - ear disorder151 reports
- Anisocoria143 reports
- Not eating124 reports
- Vestibular disorder NOS116 reports
- Nystagmus110 reports
- Falling103 reports
- Lethargy (see also Central nervous system depression in 'Neurological')103 reports
- Head shake - ear disorder89 reports
Monitoring1
Baseline liver enzymes, periodic if long-term
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Hypersensitivity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Active/chronic liver disease, significant renal impairment (manufacturer does not recommend use)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Comparatively few drug interactions vs. azole antifungals — doesn't work through CYP3A/steroidogenesis pathway, so it's often better tolerated in animals on multiple other medications.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Veterinary doses are much higher than human doses (30–40 mg/kg vs. human ~3–6 mg/kg) — do not extrapolate from human dosing.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pulse dosing in cats (1 week on, 3 weeks off) can be as effective as continuous dosing with fewer GI/hepatic side effects.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions3
Cyclosporine — May ↑ cyclosporine elimination (↓ levels) — opposite direction from azoles
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Rifampin — ↑ terbinafine clearance
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Beta-blockers, MAOIs (amitraz, selegiline), SSRIs, TCAs — Shared CYP2D6 pathway — potential interaction
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics5
Bioavailability — >46% (dog); ~31% (cat)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Protein binding — >99% (human data)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — 8.6h (dog); 8.1h (cat)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — Hepatic (CYP2D6-shared pathway)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Hepatic
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
No overt teratogenicity in rabbit/rat studies at high doses, but not established as safe. Human FDA category B; manufacturer recommends against use while nursing (7x plasma levels in milk).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1100–1101; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 792–793 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references8
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Fungicidal Activity of the Nitroimidazole-Thiosemicarbazide Derivative 1-[(1-methyl-4-nitroimidazol-2-yl)carbonyl]-4-(3-methylophenyl)thiosemicarbazide Against Trichophyton spp. Dermatophytes.
Study summary not available in the imported record. Open the original citation to review the study.
- Systemic use of terbinafine in veterinary medicine: A review of pharmacokinetic studies.
Study summary not available in the imported record. Open the original citation to review the study.
- In Vitro Antifungal Activity of Essential Oils and Nanoemulsions of Zingiber cassumunar and Cymbopogon citratus Against Planktonic and Biofilm Forms of Malassezia pachydermatis.
Study summary not available in the imported record. Open the original citation to review the study.
- Plasma concentrations of terbinafine in Kemp's ridley sea turtles (Lepidochelys kempii) peak at 24 hours after a single oral dose.
Study summary not available in the imported record. Open the original citation to review the study.
- Modified chitosan-fabricated antifungal transdermal array for dermatophytosis therapy.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.
Available products
Products listed in the Health Canada Drug Product Database for this active ingredient. A listing does not establish that a product is authorized for the clinical uses described on this page.