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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications3
Post-op pain (7-day max at higher dose); OA pain/inflammation (ongoing, lower dose)
DogOn-label (ON_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Post-op pain (7-day max at higher dose); OA pain/inflammation (ongoing, lower dose) — Authorized (FDA)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Adjunctive TCC of bladder (investigational)
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Adjunctive TCC of bladder (investigational) — Extra-label / investigational
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Single-dose analgesia
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Single-dose analgesia — Extra-label, limited PK data only
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens4
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects204
GI (vomiting, anorexia, melena, ulceration/perforation) — Most common
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Renal (azotemia, PU/PD, renal failure) — Possible, esp. at high doses
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Hepatic, hematologic, neurologic, dermatologic effects — Reported, less common
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Focal renal tubular necrosis — Seen in chronic high-dose studies (≥6 mg/kg/day)
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting3,379 reports
- Anorexia2,420 reports
- Depression1,848 reports
- Elevated blood urea nitrogen (BUN)1,672 reports
- Elevated serum alkaline phosphatase (SAP)1,610 reports
- Diarrhoea1,479 reports
- Accidental exposure1,440 reports
- Elevated creatinine1,416 reports
- Elevated alanine aminotransferase (ALT)1,311 reports
- Death by euthanasia1,246 reports
- Death1,012 reports
- Anaemia NOS867 reports
Cat
- Accidental exposure62 reports
- Vomiting37 reports
- PR-KIDNEY(S), LESION(S)23 reports
- Elevated creatinine22 reports
- Elevated blood urea nitrogen (BUN)20 reports
- PR-THYMUS, LESION(S)20 reports
- Death by euthanasia17 reports
- Loose stool17 reports
- Depression16 reports
- PR-ADRENAL(S), LESION(S)16 reports
- No sign15 reports
- PR-LYMPH NODE(S), LESION(S)14 reports
Monitoring3
Baseline + periodic CBC/serum chemistry (BUN/creatinine, liver panel)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
GI signs (diarrhea, bleeding, ulcers); renal parameters (water intake, USG)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Clinical efficacy and adverse-effect review with owner
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Hypersensitivity to drug
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
GI ulcerative disease, renal/hepatic dysfunction, hypoproteinemia, hypercoagulable states; avoid combining with other NSAIDs/corticosteroids
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Chewable tablets are palatable — store out of reach; accidental ingestion risk.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
No FDA approval for cats — single-dose use only, extra-label.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Does not appear to affect thyroid function tests.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions5
ACE inhibitors — Possible ↑ renal injury risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Aspirin, other NSAIDs, corticosteroids — ↑ GI toxicity risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Fluconazole — May raise deracoxib levels (extrapolated from celecoxib data)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Furosemide, other nephrotoxic drugs — ↑ nephrotoxicity risk, ↓ diuretic effect
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Methotrexate — Serious toxicity risk — avoid
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics5
Bioavailability — >90% PO
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Protein binding — ≥90% (dog)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — ~3h at ≤8 mg/kg; ~19h at 20 mg/kg (dog, dose-dependent, non-linear); ~8h (cat)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — Hepatic → 4 metabolites
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Principally fecal; some renal
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
No data located; use with caution — avoid unless benefit outweighs unknown risk.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 355–357; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 239–240 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references19
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Comparative disposition kinetics of oral deracoxib in sheep and goats.
Study summary not available in the imported record. Open the original citation to review the study.
- Pharmacokinetic evaluation of oral deracoxib in geese (Anser anser domesticus).
Study summary not available in the imported record. Open the original citation to review the study.
- Gastric or duodenal perforation and secondary septic peritonitis following therapeutic nonsteroidal anti-inflammatory drug administration.
Study summary not available in the imported record. Open the original citation to review the study.
- Response of cultured normal canine mammary epithelial cells to deracoxib-doxorubicin combination.
Study summary not available in the imported record. Open the original citation to review the study.
- Synergistic growth inhibitory effect of deracoxib with doxorubicin against a canine mammary tumor cell line, CMT-U27.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.
Available products
Products listed in the Health Canada Drug Product Database for this active ingredient. A listing does not establish that a product is authorized for the clinical uses described on this page.