MDose · Veterinary drug reference
CARBOPLATIN
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Osteosarcoma adjuvant (post-amputation); squamous cell, ovarian, mediastinal, pleural, nasal, thyroid carcinomas; sarcomas
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Osteosarcoma adjuvant (post-amputation); squamous cell, ovarian, mediastinal, pleural, nasal, thyroid carcinomas; sarcomas — Extra-label (human drug)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Same carcinoma spectrum (unlike cisplatin, usable); intratumoral for nasal planum SCC; intracavitary for malignant effusions
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Same carcinoma spectrum (unlike cisplatin, usable); intratumoral for nasal planum SCC; intracavitary for malignant effusions — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens4
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects45
Myelosuppression — nadir: dog day ~14 (neutrophils + platelets); cat day ~17–21 (neutrophils) — Dose-limiting
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
GI effects — Milder than cisplatin
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Hypersensitivity (platinum) — Possible
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Diarrhoea5 reports
- Vomiting5 reports
- Bloody diarrhoea2 reports
- Dehydration2 reports
- Elevated creatinine2 reports
- Hyperalbuminaemia2 reports
- Hypercalcaemia2 reports
- Neutropenia2 reports
- Abnormal ultrasound finding1 reports
- Anaemia NOS1 reports
- Anorexia1 reports
- Azotaemia1 reports
Cat
- Vomiting1 reports
Monitoring1
CBC at nadir (day 14 dog / day 17–21 cat) and before next cycle; renal values; infusion reactions
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Platinum hypersensitivity; severe marrow depression
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions5
Hepatic/renal disease, hearing impairment, active infection; may blunt vaccine safety/efficacy
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Carboplatin = the platinum you can give to cats (cisplatin kills them — pulmonary edema); the dog dose is ~10× the cisplatin dose — a swap without recalculating is a fatal error in either direction.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Osteosarcoma adjuvant post-amputation is the flagship use; TCC of the bladder disappointing systemically.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The D5W-only rule is a pharmacy/dispensing detail that actually matters (unlike many fluid-compat caveats).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Long feline nadir (up to day 21) — schedule the recheck accordingly.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions3
Nephrotoxins (aminoglycosides — cisplatin rule) — Class caution though carboplatin gentler
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Other myelosuppressives — Additive
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Meloxicam/NSAIDs — Deliberate intra-arterial combo for TCC (investigational)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Mechanism — Platinum-DNA crosslinking (like cisplatin) with less renal/GI/ototoxicity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Administration — D5W only (saline → incompatibility/chloride reactions); reconstituted 10 mg/mL stable ~8–24 h
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Renal — dose adjust in dysfunction
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Fetotoxic — avoid.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 195–196 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references20
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Chylopericardium in a Dog with Concurrent Chylothorax, Mesothelioma, and Bilateral Brachiocephalic Vein Thrombosis: A Case Report.
Study summary not available in the imported record. Open the original citation to review the study.
- Electrochemotherapy with carboplatin and bleomycin associated with mastectomy in cats with mammary carcinoma: A pilot study.
Study summary not available in the imported record. Open the original citation to review the study.
- Use of the IlluminOss Photodynamic Bone Stabilisation System Following Stereotactic Body Radiation Therapy for Limb-Sparing in Six Dogs With Presumptive Appendicular Osteosarcoma.
Study summary not available in the imported record. Open the original citation to review the study.
- Leverage of quick-soluble gelatin microparticles in transarterial chemoembolization of canine urothelial carcinomas.
Study summary not available in the imported record. Open the original citation to review the study.
- The Co-Administration of Fluoroquinolones Strongly Increases the Anticancer Efficacy of Carboplatin Treatment-Novel Insights for Breast Cancer Chemotherapy from the Canine Mammary Tumor Model.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.