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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Dose regimens2
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
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Adverse effects114
Diabetes mellitus induction, pyometra, mammary tumors, adrenal suppression, weight gain
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Polydipsia3 reports
- Polyuria3 reports
- Depression2 reports
- INEFFECTIVE, ESTRUS SUPPRESSIO2 reports
- Lack of efficacy - NOS2 reports
- Abnormal oestrus NOS1 reports
- Accidental exposure1 reports
- Alopecia NOS1 reports
- Bloody diarrhoea1 reports
- Death1 reports
- Diabetes mellitus1 reports
- Error occurred in home1 reports
Cat
- Diabetes mellitus15 reports
- Death by euthanasia8 reports
- Diabetes8 reports
- Polydipsia8 reports
- Mammary gland neoplasm NOS6 reports
- Mammary hyperplasia6 reports
- Polyuria6 reports
- Anorexia5 reports
- Glucosuria5 reports
- Hyperglycaemia5 reports
- Weight loss5 reports
- Depression4 reports
Interactions1
Insulin resistance — diabetic destabilization
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references20
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Efficacy, safety and interval from end of treatment to estrus in cats treated with an ultra-low dose megestrol acetate protocol for suppression of reproductive activity.
Study summary not available in the imported record. Open the original citation to review the study.
- Environmental assessment of steroid endocrine disruptors in stranded cetaceans: A methodological approach to detection and analysis.
Study summary not available in the imported record. Open the original citation to review the study.
- Simplified Liquid Chromatography-Mass Spectrometry Methods for Gestagen Analysis in Animal Fat and Liver.
Study summary not available in the imported record. Open the original citation to review the study.
- Characterizing the dissolution profiles of supersaturable salts, cocrystals, and solvates to enhance in vivo oral absorption.
Study summary not available in the imported record. Open the original citation to review the study.
- Use of an ophthalmic formulation of megestrol acetate for the treatment of eosinophilic keratitis in cats.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.