MDose · Veterinary drug reference
OMEPRAZOLE
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Gastroduodenal ulcers/erosions, esophagitis, uremic gastropathy, NSAID-associated GI injury, Helicobacter adjunct
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Gastroduodenal ulcers/erosions, esophagitis, uremic gastropathy, NSAID-associated GI injury, Helicobacter adjunct — Extra-label (no small-animal-labeled product)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Gastroduodenal ulcers/erosions, esophagitis, uremic gastropathy, NSAID-associated GI injury, Helicobacter adjunct — Extra-label (no small-animal-labeled product)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens5
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects204
Diarrhea — Occasional
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Generally very well tolerated — —
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
GI distress, hematologic changes, UTI, proteinuria, CNS disturbance (theoretical) — Rare/potential
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting287 reports
- Diarrhoea179 reports
- Lethargy (see also Central nervous system depression in 'Neurological')142 reports
- Death by euthanasia126 reports
- Anorexia120 reports
- Lethargy (see also Central nervous system depression in Neurological)113 reports
- Other abnormal test result NOS109 reports
- Not eating108 reports
- Elevated alanine aminotransferase (ALT)106 reports
- Decreased appetite103 reports
- Weight loss96 reports
- Elevated serum alkaline phosphatase (SAP)83 reports
Cat
- Weight loss8 reports
- Anorexia5 reports
- Behavioural disorder NOS5 reports
- Decreased appetite5 reports
- Diarrhoea5 reports
- Death4 reports
- Intentional misuse4 reports
- Lack of efficacy - NOS4 reports
- Lethargy (see also Central nervous system depression in Neurological)4 reports
- Vomiting4 reports
- Anaemia NOS3 reports
- Dehydration3 reports
Monitoring1
Clinical efficacy; gastrin levels require 7-day washout before testing (omeprazole raises serum gastrin during treatment)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Hypersensitivity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Hepatic/renal disease (may need dose adjustment)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Superior to famotidine for sustained acid suppression in head-to-head small-animal studies — omeprazole once daily outperformed famotidine twice daily.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
No FDA-approved small-animal formulation exists — human capsules or diluted equine paste are commonly used; be skeptical of compounded products from non-FDA source material (documented low potency in equine studies).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Give before a meal, preferably in the morning, for best effect.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions5
Ketoconazole, itraconazole, iron, ampicillin esters — ↓ absorption (need acidic stomach) — avoid concurrent
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Clarithromycin — ↑ levels of both drugs
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cyclosporine — ↓ metabolism, ↑ levels
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Warfarin — ↑ anticoagulant effect
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Diazepam/benzodiazepines — May prolong CNS effects
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics5
Bioavailability — Degrades in acid — needs enteric coating/buffering; reduced by food
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Protein binding — ~95% (human data)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — ~1h (dog/human)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — Extensive hepatic (≥6 metabolites)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Urine + bile/feces
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
No teratogenicity at very high doses in rats; increased embryo-lethality at very high doses. Human FDA category C. Unknown if in milk; rat pup weight gain ↓ at very high maternal doses.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 906–909; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 577–608 (monograph pages 577–580) — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references16
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Genetic polymorphisms of drug-metabolizing cytochromes P450 and flavin-containing monooxygenases in dogs and pigs inform the prediction of drug metabolism and toxicity in humans and other animal species.
Study summary not available in the imported record. Open the original citation to review the study.
- Evaluation of Human-Approved Active Pharmaceutical Ingredients Against Lactate Dehydrogenase from Theileria annulata.
Study summary not available in the imported record. Open the original citation to review the study.
- Effects of syringic acid on the indomethacin-induced gastric ulcer model in rats: in vivo and in silico study.
Study summary not available in the imported record. Open the original citation to review the study.
- Boswellia serrata dry extract with intestinal anti-inflammatory properties also accelerates gastric ulcer healing in rats.
Study summary not available in the imported record. Open the original citation to review the study.
- Comparative pharmacokinetic dispositions of omeprazole and its metabolites following intravenous and oral administration in sheep and goats.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
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