MDose · Veterinary drug reference
FLUCONAZOLE
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
CNS/ocular fungal infections (cryptococcal meningitis), fungal UTI, blastomycosis, Malassezia dermatitis
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: CNS/ocular fungal infections (cryptococcal meningitis), fungal UTI, blastomycosis, Malassezia dermatitis — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: CNS/ocular fungal infections (cryptococcal meningitis), fungal UTI, blastomycosis, Malassezia dermatitis — Extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens4
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects204
Inappetence, vomiting, diarrhea — Occasional
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Hepatotoxicity — Possible, generally less than ketoconazole
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Toxic to budgerigars — —
AvianNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Avian · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting52 reports
- Lethargy (see also Central nervous system depression in 'Neurological')41 reports
- Lack of efficacy - NOS34 reports
- Diarrhoea32 reports
- Other abnormal test result NOS32 reports
- Weight loss20 reports
- Emesis19 reports
- Anorexia18 reports
- Not eating18 reports
- Elevated alanine aminotransferase (ALT)17 reports
- Death15 reports
- Death by euthanasia15 reports
Cat
- Lethargy (see also Central nervous system depression in 'Neurological')7 reports
- Vomiting7 reports
- Behavioural disorder NOS5 reports
- Death by euthanasia5 reports
- Other abnormal test result NOS5 reports
- Weight loss5 reports
- Elevated alanine aminotransferase (ALT)4 reports
- Not eating4 reports
- Anorexia3 reports
- Dermatitis3 reports
- Diarrhoea3 reports
- Elevated liver enzymes3 reports
Monitoring1
Periodic liver function tests with long-term therapy
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Azole hypersensitivity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Renal impairment (dose/interval adjustment needed); hepatic impairment
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Best azole choice for CNS, ocular, and fungal urinary tract infections due to superior CSF/urine penetration and minimal protein binding.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Fewer endocrine side effects than ketoconazole (doesn't significantly suppress cortisol/testosterone) — a reasonable alternative in dogs with hepatic disease where itraconazole/ketoconazole are riskier.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Treatment courses are often prolonged (months) — cost can become a major limiting factor, especially in cats at higher doses.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions5
Cyclosporine — ↑ levels significantly — in dogs, allowed 29–51% cyclosporine dose reduction
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Midazolam, other benzodiazepines — ↑ levels/effect
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Warfarin — ↑ PT/bleeding risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Theophylline — ↑ levels
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Amphotericin B — Possible antagonism against Aspergillus/Candida (lab data)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics5
Bioavailability — ~90% PO — not significantly affected by food/gastric pH (unlike keto/itraconazole)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Protein binding — Low
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — 14–15h (dog); 13–25h (cat, wide range); ~30h (human)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — Minimal
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Primarily renal, high urine concentrations
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Not established; avoid unless benefit outweighs risk. Human FDA category C. Excreted in milk at levels similar to plasma.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 528–531; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 329–330 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references16
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Thiazolyl-Methylthio-1,3,4-Thiadiazole Hybrids as Halicin Analogues with Antimicrobial and Antibiofilm Activities: Chemical Development, Biological Assessment, and 2D-QSAR Study.
Study summary not available in the imported record. Open the original citation to review the study.
- Nano-Encapsulated Cinnamomum cassia Essential Oil in Combination With Fluconazole Exhibits Synergistic Activity Against Fluconazole-Resistant Nakaseomyces glabratus and Pichia kudriavzevii.
Study summary not available in the imported record. Open the original citation to review the study.
- The Potential Role of Verapamil Against Fluconazole-Induced Torsade de Pointes: A Critical Review.
Study summary not available in the imported record. Open the original citation to review the study.
- New isoxazole-based heterocyclic hybrids with dual antimicrobial and antioxidant bioactivity: integrated synthesis, in vitro assessment, and computational exploration.
Study summary not available in the imported record. Open the original citation to review the study.
- Bioactive flavonoids from Anacardium occidentale as promising natural inhibitors of Cryptococcus neoformans: a computational perspective on secondary metabolites against critical fungal pathogens.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.