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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Obsessive-compulsive/ritualistic stereotypic behaviors, separation anxiety, storm phobia (adjunct)
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Obsessive-compulsive/ritualistic stereotypic behaviors, separation anxiety, storm phobia (adjunct) — Clomicalm labeled for separation anxiety (dogs)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Urine spraying/marking
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Urine spraying/marking — Extra-label; not effective for psychogenic alopecia
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens5
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects205
Anorexia, emesis, diarrhea, ↑liver enzymes, sedation/lethargy — Primary reported effects
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Anticholinergic effects (dry mouth, tachycardia) — Rare at therapeutic doses
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Sedation, weight gain — More pronounced than in dogs (slower metabolite clearance)
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Urine retention
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Table 1 (p.630), row: Clomipramine, Adverse Effects column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
- Cat · Table 1 (p.630), row: Clomipramine, Adverse Effects column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Depression322 reports
- Vomiting257 reports
- Accidental exposure192 reports
- Elevated alanine aminotransferase (ALT)192 reports
- Elevated serum alkaline phosphatase (SAP)169 reports
- Anorexia168 reports
- Lack of efficacy - NOS155 reports
- Diarrhoea120 reports
- Aggression107 reports
- Ataxia86 reports
- Elevated total bilirubin82 reports
- Elevated aspartate aminotransferase (AST)74 reports
Cat
- Depression28 reports
- Mydriasis21 reports
- Accidental exposure20 reports
- Anorexia18 reports
- Urinary tract disorder NOS11 reports
- Vomiting11 reports
- Constipation10 reports
- Vocalisation10 reports
- Weight loss10 reports
- Elevated alanine aminotransferase (ALT)9 reports
- Tachycardia9 reports
- Behavioural disorder NOS8 reports
Monitoring1
Baseline + annual liver enzymes for long-term therapy; heart rate/rhythm (ECG at baseline recommended); clinical efficacy (may take 4–6 weeks)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications3
Prior TCA hypersensitivity; concurrent MAO inhibitors
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
MAOIs, cardiac arrhythmias
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Table 1 (p.630), row: Clomipramine, Contraindications column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
- Cat · Table 1 (p.630), row: Clomipramine, Contraindications column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
Precautions4
Cardiac disease (rhythm disturbances); pre-existing seizure disorders (may lower threshold); avoid aged cheeses/high-tyramine foods
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Superior to amitriptyline for compulsive disorders in dogs, but not effective for dominance-related aggression.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
In cats, urine-marking relapses quickly (abruptly) after drug discontinuation — set owner expectations for a longer-term commitment or plan for tapering with behavioral support.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Narrow margin of safety — clinical signs can appear at only 2–3× therapeutic dose; treat any suspected overdose as an emergency.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions5
MAO inhibitors (selegiline, amitraz) — Contraindicated within 14 days — serotonin syndrome risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
SSRIs (fluoxetine, paroxetine, sertraline) — ↑ serotonin syndrome risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cimetidine — ↓ TCA metabolism, ↑ toxicity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cisapride, quinidine — ↑ QTc prolongation risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Meperidine, pentazocine, dextromethorphan — ↑ serotonin syndrome risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics4
Bioavailability — ~20% oral (dog, Papich); active metabolite desmethylclomipramine formed rapidly
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Protein binding — 96% (parent + metabolite)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — ~5h single dose (dog), may shorten to 2–4h with repeated dosing; desmethylclomipramine ~69h
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
No teratogenicity in rodent studies up to 20× max human dose. Not for use in breeding male dogs — high-dose studies showed testicular atrophy. Human FDA category C.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 296–298; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 174–175 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references19
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Does treatment with clomipramine reduce cat psychogenic alopecia?
Study summary not available in the imported record. Open the original citation to review the study.
- Use of mirtazapine in the treatment of canine behaviour problems: A review of 32 cases.
Study summary not available in the imported record. Open the original citation to review the study.
- Dopamine Abundance Uncouples Neurodegeneration and Lifespan in a C. elegans Model of Parkinson's Disease.
Study summary not available in the imported record. Open the original citation to review the study.
- Repeated intranasal esketamine augmentation in treatment-resistant obsessive-compulsive disorder with comorbid major depressive disorder: a prospective case series.
Study summary not available in the imported record. Open the original citation to review the study.
- Concurrent Use of Tasipimidine Oral Solution and Clomipramine in Dogs.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Perrin C, Seksel K, Landsberg GM. Appendix: Drug Dosage Chart. Vet Clin Small Anim 2014;44:629-632.; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.
Available products
Products listed in the Health Canada Drug Product Database for this active ingredient. A listing does not establish that a product is authorized for the clinical uses described on this page.