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Choose the species
One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Fleas, ticks, chewing lice (label); extra-label successes: chiggers (Trombicula), sarcoptic mange, cheyletiellosis, otoacariosis
DogCatOn-label (ON_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1243–1244 (topical appendix) — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Fleas, ticks, chewing lice (label); extra-label successes: chiggers (Trombicula), sarcoptic mange, cheyletiellosis, otoacariosis — OTC/EPA-registered (pesticide, not FDA drug)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1243–1244 (topical appendix) — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Fleas, ticks, chewing lice (label); extra-label successes: chiggers (Trombicula), sarcoptic mange, cheyletiellosis, otoacariosis — OTC/EPA-registered (pesticide, not FDA drug)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1243–1244 (topical appendix) — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens2
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects203
Hypersensitivity — Rare
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1243–1244 (topical appendix) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Temporary application-site irritation; wet/oily appearance ≤24 h — Common, minor
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1243–1244 (topical appendix) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Permethrin confusion-alert — Fipronil CAT-safe; K9 Advantix (permethrin) is the dog-only product — permethrin is highly toxic to cats
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1243–1244 (topical appendix) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Lethargy (see also Central nervous system depression in 'Neurological')1,015 reports
- Lack of efficacy (ectoparasite) - flea999 reports
- Vomiting924 reports
- Diarrhoea431 reports
- Seizure NOS356 reports
- Behavioural disorder NOS354 reports
- Emesis354 reports
- Lack of efficacy - NOS254 reports
- Restlessness228 reports
- Itching223 reports
- Scratching219 reports
- Anorexia202 reports
Cat
- Lack of efficacy (ectoparasite) - flea279 reports
- Lethargy (see also Central nervous system depression in 'Neurological')104 reports
- Vomiting80 reports
- Hyperactivity78 reports
- Panting71 reports
- Emesis53 reports
- Lack of efficacy (flea)44 reports
- Scratching43 reports
- Vocalisation42 reports
- Behavioural disorder NOS41 reports
- Pruritus38 reports
- Application site hair loss35 reports
Monitoring1
Flea/tick counts; application-site reactions
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1243–1244 (topical appendix) — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Avoid human contact until dry; kittens/puppies per label age minimums
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1243–1244 (topical appendix) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacy-law note: Frontline = EPA pesticide (OTC), Comfortis = FDA drug (Rx) — same shelf-space problem, different regulatory worlds.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1243–1244 (topical appendix) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Mechanism trio for the exam: fipronil = GABA-chloride, imidacloprid = nicotinic-ACh, permethrin = sodium-channel.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1243–1244 (topical appendix) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The oils-and-follicles depot explains both the 24-hour spread and the residual — and why shampooing within 48 h undermines the application.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1243–1244 (topical appendix) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions1
Other topicals at same site — Space applications
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1243–1244 (topical appendix) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics4
Mechanism — Phenylpyrazole: blocks GABA-gated chloride channels (insect CNS) → death
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1243–1244 (topical appendix) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Distribution — Collects in skin oils/follicles, released over time — spreads over body ~24 h by translocation
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1243–1244 (topical appendix) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Methoprene (Plus) — IGR — breaks egg/larval development
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1243–1244 (topical appendix) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Bathing — Label claims effectiveness survives bathing/water immersion/sunlight (minus 48-h rule)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1243–1244 (topical appendix) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Label statements per product (generally permitted).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1243–1244 (topical appendix) — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references16
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- A questionnaire-based survey on the efficacy of antiparasitic products against ectoparasites of companion and livestock animals in Denmark.
Study summary not available in the imported record. Open the original citation to review the study.
- Standardization of an in vitro test for doramectin, fipronil, chlorpyrifos, and fluralaner against Cochliomyia hominivorax (Diptera: Calliphoridae) larvae.
Study summary not available in the imported record. Open the original citation to review the study.
- Insecticide resistance level and geographical distribution of target-site mutations in field collections of the house fly (Musca domestica) from Türkiye.
Study summary not available in the imported record. Open the original citation to review the study.
- Fipronil chewable tablets: development, pharmacokinetic profile, and efficacy in treating beagles naturally infested with Cochliomyia hominivorax.
Study summary not available in the imported record. Open the original citation to review the study.
- Plasma Pharmacokinetic Profile of Fipronil 1% Pour-On in Cattle: Photodegradation and the Sustained Systemic Persistence of Fipronil Sulfone.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.