MDose · Veterinary drug reference
CARPROFEN
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Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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Indications5
Musculoskeletal/OA pain, post-op/surgical pain
DogOn-label (ON_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Musculoskeletal/OA pain, post-op/surgical pain — Authorized
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Single-dose peri-operative analgesia only
CatOn-label (ON_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Single-dose peri-operative analgesia only — Authorized (EU) — chronic use not established
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
® OstiFenis indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs.
DogOn-label (ON_LABEL)United States1 source record · View provenance
- Dog · SPL section 34067-9 (INDICATIONS & USAGE SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Levafen is indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs.
DogOn-label (ON_LABEL)United States1 source record · View provenance
- Dog · SPL section 34067-9 (INDICATIONS & USAGE SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Carprofen Injectable is indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs.
DogOn-label (ON_LABEL)United States1 source record · View provenance
- Dog · SPL section 34067-9 (INDICATIONS & USAGE SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens11
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
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Adverse effects209
GI (vomiting, anorexia, diarrhea) — Most common, usually mild (<2%)
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Idiosyncratic acute hepatotoxicity — Rare (~0.05%), typically 2–3 weeks after starting
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Renal toxicity — Rare; risk ↑ with dehydration/pre-existing renal disease
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Accumulation toxicity at dog doses — Significant risk — cats poorly glucuronidate
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
During investigational studies for the caplet formulation, no clinically significant adverse reactions were reported. Some clinical signs were observed during field studies (n=297) which were similar for carprofen- and placebo-treated dogs. Incidences of the following were observed in both groups: vomiting (4%), diarrhea (4%), changes in appetite (3%), lethargy (1.4%), behavioral changes (1%), and constipation (0.3%). The product vehicle served as control. There were no serious adverse events reported during clinical field studies with once daily oral administration of 2 mg/lb. The following categories of abnormal health observations were reported. The product vehicle served as control. Percentage of Dogs with Abnormal Health Observations Reported in Clinical Field Study (2 mg/lb once daily) Clinical pathology parameters listed represent reports of increases from pre-treatment values; the use of clinical judgement is necessary to determine clinical relevance (refers also to table below). There were no serious adverse events reported during clinical field studies for the injectable formulation. The following categories of abnormal health observations were reported. Saline served as placebo control. Percentage of Dogs with Abnormal Health Observations Reported in Clinical Field Studies with the Injectable * A single dog may have experienced more than one occurrence of an event. Observation Carprofen (n=129) Placebo (n=132) Inappetence 1.6 1.5 Vomiting 3.1 3.8 Diarrhea/Soft stool 3.1 4.5 Behavior change 0.8 0.8 Dermatitis 0.8 0.8 PU/PD 0.8 - SAP increase 7.8 8.3 ALT increase 5.4 4.5 AST increase 2.3 0.8 BUN increase 3.1 1.5 Bilirubinuria 16.3 12.1 Ketonuria 14.7 9.1 Observation* Carprofen (n=168) Placebo (n=163) Vomiting 10.1 9.2 Diarrhea/soft stool 2.4 3.7 Dermatitis 0.6 1.2 Dysrhythmia 0.6 0.6 Swelling 0 1.2 Dehiscence 1.2 0 WBC increase 13.7 6.7
DogOn-label (ON_LABEL)United States3 source records · View provenance
- Dog · SPL section 34084-4 (ADVERSE REACTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
- Dog · SPL section 34084-4 (ADVERSE REACTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
- Dog · SPL section 34084-4 (ADVERSE REACTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting12,429 reports
- Anorexia9,595 reports
- Elevated alanine aminotransferase (ALT)8,565 reports
- Elevated serum alkaline phosphatase (SAP)7,598 reports
- Depression5,983 reports
- Diarrhoea5,141 reports
- Elevated total bilirubin4,414 reports
- Death by euthanasia4,316 reports
- Death4,191 reports
- Accidental exposure4,133 reports
- Elevated blood urea nitrogen (BUN)3,392 reports
- Elevated creatinine2,938 reports
Cat
- Accidental exposure1,241 reports
- No sign707 reports
- Vomiting386 reports
- Depression245 reports
- Anorexia232 reports
- Elevated blood urea nitrogen (BUN)189 reports
- Elevated creatinine179 reports
- Death108 reports
- Elevated alanine aminotransferase (ALT)84 reports
- Dehydration72 reports
- Hyperphosphataemia63 reports
- Death by euthanasia56 reports
Monitoring2
Baseline + periodic CBC/serum chemistry (esp. hepatic enzymes ~7–14 days after starting, renal panel)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Clinical efficacy and GI/behavioral adverse-effect checks with owner
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications5
Bleeding disorders (e.g., von Willebrand's); prior serious NSAID reaction; do not dose cats at canine doses
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
® OstiFenshould not be used in dogs exhibiting previous hypersensitivity to carprofen.
DogOn-label (ON_LABEL)United States1 source record · View provenance
- Dog · SPL section 34070-3 (CONTRAINDICATIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Levafen should not be used in dogs exhibiting previous hypersensitivity to carprofen.
DogOn-label (ON_LABEL)United States1 source record · View provenance
- Dog · SPL section 34070-3 (CONTRAINDICATIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Carprofen Injectable should not be used in dogs exhibiting previous hypersensitivity to carprofen.
DogOn-label (ON_LABEL)United States1 source record · View provenance
- Dog · SPL section 34070-3 (CONTRAINDICATIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Rimadyl should not be used in dogs exhibiting previous hypersensitivity to carprofen.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34070-3 (CONTRAINDICATIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Precautions12
Geriatric/chronic disease patients (renal, hepatic, IBD); avoid with other ulcerogenic drugs
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Never dose cats at canine mg/kg rates — cat use is single-dose only.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Hepatopathy is idiosyncratic and not clearly dose-related; stop drug and recheck liver enzymes if signs occur.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
No credible evidence requires an NSAID washout period beyond starting the next drug at the next scheduled dose (except when switching to/from aspirin — allow several days).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
For use in dogs only Keep out of reach of children. Not for human use. Consult a physician in cases of accidental human exposure.. Do not use in cats. Owners should be advised to observe for signs of potential drug toxicity (see Adverse Reactions, Animal Safety and Post-Approval Experience). All dogs should undergo a thorough history and physical examination before initiation of NSAID therapy. Appropriate laboratory tests to establish hematological and serum biochemical baseline data prior to, and periodically during, administration of any NSAID should be considered.
DogSpecies not recordedOn-label (ON_LABEL)United States4 source records · View provenance
- Dog · SPL section 34071-1 (WARNINGS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
- Dog · SPL section 34071-1 (WARNINGS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
- Dog · SPL section 34071-1 (WARNINGS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
- Species not recorded · SPL section 34071-1 (WARNINGS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Interactions7
ACE inhibitors (benazepril, enalapril) — Combined renal blood flow reduction — ↑ renal injury risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Aspirin — ↓ carprofen levels, ↑ GI bleeding risk — avoid concurrent use
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Corticosteroids, other NSAIDs — ↑ GI ulceration risk — avoid combination
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Digoxin — Carprofen may raise digoxin levels
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Furosemide — Reduced diuretic/saluretic effect
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics9
Bioavailability — ~90% PO
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Protein binding — ~99%
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — ~8h (dog); ~20h (cat, range 9–49h); ~22h (horse); 30–40h (cattle)
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — Hepatic, primarily glucuronidation
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — 70–80% feces, 10–20% urine
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Safety not established in pregnant/breeding/lactating dogs or cats. In rat studies, high doses delayed parturition and increased pup mortality without teratogenicity.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 198–200; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 138–140 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references18
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Favorable pharmacokinetic and tolerability profiles make carprofen an attractive analgesic for subcutaneous injection and oral self-administration in rats.
Study summary not available in the imported record. Open the original citation to review the study.
- Current practices of pain assessment and analgesic use in laboratory mice: A 2022 FELASA Working Group survey.
Study summary not available in the imported record. Open the original citation to review the study.
- Development of a Carprofen-Loaded Nanoemulsion for Topical Management of Post-Surgical Inflammation.
Study summary not available in the imported record. Open the original citation to review the study.
- Toward animal-free approaches in subcutaneous drug delivery: A pain management case study.
Study summary not available in the imported record. Open the original citation to review the study.
- Randomized and Blind Evaluation of the Efficacy of a Full-Spectrum Oral Cannabis sativa Oil Extract, Standardized Based on CBD-A, CBD and THC-A, THC in Canines with Chronic Osteoarthritis.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: DailyMed, U.S. National Library of Medicine; PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.
Available products
Products listed in the Health Canada Drug Product Database for this active ingredient. A listing does not establish that a product is authorized for the clinical uses described on this page.