MDose · Veterinary drug reference
AMOXICILLIN CLAVULANATE
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
UTI, skin/soft tissue infection, canine periodontal disease
DogCatOn-label (ON_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: UTI, skin/soft tissue infection, canine periodontal disease — Authorized (FDA)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: UTI, skin/soft tissue infection, canine periodontal disease — Authorized (FDA)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens4
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects204
GI (diarrhea common, vomiting) — ↑ with higher clavulanate proportion
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Hypersensitivity reactions — Uncommon
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Neurotoxicity (high dose/prolonged) — Rare
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting423 reports
- Lack of efficacy (bacteria) - NOS338 reports
- Anorexia320 reports
- Depression285 reports
- Death186 reports
- Elevated alanine aminotransferase (ALT)168 reports
- Elevated serum alkaline phosphatase (SAP)163 reports
- Death by euthanasia136 reports
- Diarrhoea133 reports
- Anaemia NOS127 reports
- Ataxia113 reports
- Leucocytosis NOS109 reports
Cat
- Vomiting360 reports
- Anorexia198 reports
- Lack of efficacy (bacteria) - NOS167 reports
- Depression160 reports
- Diarrhoea148 reports
- Death100 reports
- Death by euthanasia68 reports
- Fever57 reports
- Ataxia55 reports
- Dehydration51 reports
- Elevated blood urea nitrogen (BUN)50 reports
- Anaemia NOS46 reports
Monitoring1
Clinical efficacy; minimal routine lab monitoring needed
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Beta-lactam hypersensitivity; rabbits/rodents/guinea pigs (enterotoxemia risk)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Not orally absorbed in large animals — not recommended for that route/species
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Veterinary formulation is a 4:1 amoxicillin:clavulanate ratio; human Augmentin ranges 2:1 to 7:1 — do not substitute doses interchangeably without checking the ratio.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Some dermatologists double the labeled dose (25 mg/kg q12h) for skin infections.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Not useful orally in large animals — poor absorption of amoxicillin component.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions3
Bacteriostatic antimicrobials — Theoretical antagonism
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Methotrexate — ↑ MTX toxicity risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Probenecid — ↑ levels/half-life
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics5
Metabolism — Clavulanate extensively hepatic (dog/rat)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Renal (both components) + fecal
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Bioavailability — Amoxicillin component: 50–60% (small animals)
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Protein binding — Clavulanate ~13% (dog)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — Same as amoxicillin (45–90 min)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Papich canine/feline class A (probably safe). Both components cross placenta, low levels in milk.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 87–89; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 39–40 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references18
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Perplexing pneumonia: Pasteurella lung infection.
Study summary not available in the imported record. Open the original citation to review the study.
- Curcumin shows promise as an adjunct in changing β-lactam susceptibility status of canine multidrug-resistant Staphylococcus pseudintermedius: an in vitro study.
Study summary not available in the imported record. Open the original citation to review the study.
- Oral administration of Enterococcus lactis strain SF68 speeds the recovery of amoxicillin-clavulanate-induced dysbiosis in cats.
Study summary not available in the imported record. Open the original citation to review the study.
- Retrospective Determination of the Incidence of Apparent Type I Hypersensitivity Reaction to Intravenous Amoxicillin-Clavulanate in Dogs and Cats.
Study summary not available in the imported record. Open the original citation to review the study.
- Molecular characterization of multidrug-resistant and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolated from Sonali chicken meat in Bangladesh.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.