MDose · Veterinary drug reference
TIER2 TOPIC: ENDOCRINE STRAGGLERS (GLIPIZIDE / CALCITRIOL / MEGESTROL ± DES)
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Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications6
Glipizide: non-insulin option for non-ketotic, relatively healthy diabetics (declining use vs glargine)
CatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Glipizide: non-insulin option for non-ketotic, relatively healthy diabetics (declining use vs glargine) — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Calcitriol: suppress secondary renal hyperparathyroidism in CKD (dogs; cats debated)
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Calcitriol: suppress secondary renal hyperparathyroidism in CKD (dogs; cats debated) — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Calcitriol: suppress secondary renal hyperparathyroidism in CKD (dogs; cats debated) — Extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Megestrol acetate: feline dermatologic/behavioral progestin (delay estrus, some skin conditions); canine urinary incontinence alternative — heavy adverse-effect tax
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Megestrol acetate: feline dermatologic/behavioral progestin (delay estrus, some skin conditions); canine urinary incontinence alternative — heavy adverse-effect tax — Extra-label (largely superseded)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Megestrol acetate: feline dermatologic/behavioral progestin (delay estrus, some skin conditions); canine urinary incontinence alternative — heavy adverse-effect tax — Extra-label (largely superseded)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
DES: sphincter-mechanism incontinence at micro-doses (estrogen-responsive)
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: DES: sphincter-mechanism incontinence at micro-doses (estrogen-responsive) — Extra-label (compounded; human withdrawal)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens0
No dose regimens recorded for this species selection.
Adverse effects0
No adverse effects or event reports recorded for this species selection.
Monitoring3
Glipizide: glucose curves, weight, urine ketones, fructosamine — expect weeks; escalation-to-insulin trigger
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Calcitriol: Ca²⁺ + P q2–4 wk (hold if Ca↑), renal values
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Megestrol/DES: glucose, genital discharge/mammary exam, CBC (DES)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions6
DKA, ketoacidotic or insulinopenic patients; keto-check before starting
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Hypercalcemia; uncontrolled hyperphosphatemia (mineralization) — control P first
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Intact/breeding animals; diabetic patients (megestrol); mammary/genital disease history
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Glipizide's patient: the chubby, well, non-ketotic newly-diabetic cat whose owner refuses insulin — a trial with honest exit criteria (weeks, then insulin).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Calcitriol's nanogram world: 2.5–3.5 ng/kg/day AFTER phosphate control — dosing-unit errors here are orders of magnitude, not percentages.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics4
Glipizide — Sulfonylurea → pancreatic insulin release — needs functional β-cells; useless in DKA/advanced DM
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Calcitriol — Active vit D → ↑Ca/P gut absorption + direct PTH suppression; calcemic at high doses — nanogram dosing discipline
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Megestrol — Progestin: glucocorticoid-like effects, mammary stimulation, insulin antagonism (diabetes risk), pyometra risk (cats)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
DES — Estrogen → urethral-sphincter receptor sensitivity
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Sources: Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.