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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications4
Adjunctive therapy for refractory/complex partial seizures
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Adjunctive therapy for refractory/complex partial seizures — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Adjunctive therapy for refractory/complex partial seizures — Extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Chronic/neuropathic pain, adjunctive analgesia (incl. peri-op)
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Chronic/neuropathic pain, adjunctive analgesia (incl. peri-op) — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Chronic/neuropathic pain, adjunctive analgesia (incl. peri-op) — Extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens7
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects206
Sedation, ataxia — Most common, dose-related
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Withdrawal-precipitated seizures — With abrupt discontinuation
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Sedation
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Table 1 (p.630), row: Gabapentin, Adverse Effects column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
- Cat · Table 1 (p.630), row: Gabapentin, Adverse Effects column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting1,377 reports
- Diarrhoea1,023 reports
- Death by euthanasia993 reports
- Lethargy (see also Central nervous system depression in Neurological)884 reports
- Not eating708 reports
- Lack of efficacy - NOS702 reports
- Elevated alanine aminotransferase (ALT)604 reports
- Decreased appetite575 reports
- Lethargy (see also Central nervous system depression in 'Neurological')553 reports
- Ataxia542 reports
- Seizure NOS529 reports
- Panting519 reports
Cat
- Lethargy (see also Central nervous system depression in Neurological)228 reports
- Vomiting219 reports
- Not eating208 reports
- Weight loss179 reports
- Lack of efficacy - NOS171 reports
- Behavioural disorder NOS160 reports
- Death by euthanasia157 reports
- Diarrhoea146 reports
- Anorexia127 reports
- Decreased appetite113 reports
- Ataxia99 reports
- Death91 reports
Monitoring2
Clinical efficacy and sedation/ataxia; serum levels not routinely monitored (therapeutic range ~4–16 mcg/mL if checked)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Sulfosalicylic acid precipitation test for urine protein if on gabapentin (false-positive on dipstick methods)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications3
Hypersensitivity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Severe renal dysfunction
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Table 1 (p.630), row: Gabapentin, Contraindications column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
- Cat · Table 1 (p.630), row: Gabapentin, Contraindications column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
Precautions4
Renal insufficiency (dose adjust, though dogs partially compensate via hepatic metabolism); avoid human oral solution in dogs (xylitol)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Do not stop abruptly in seizure patients — wean off.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Human oral solution (Neurontin®) contains xylitol — never dispense to dogs without confirming xylitol-free formulation.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Not very effective as sole anticonvulsant; used as an add-on.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions3
Antacids — ↓ gabapentin bioavailability by ~20% — separate dosing by ≥2h
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Hydrocodone — Bidirectional PK interaction — altered levels/efficacy of both
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Morphine — May increase gabapentin levels
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics5
Bioavailability — ~80% (dog); ~90% avg, 50–120% range (cat)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Protein binding — Minimal
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — 2–4h (dog); 2.8h (cat); 3.4–8h (horse)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — 30–40% hepatic (dog); minimal (cat, human)
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Renal (unchanged + N-methyl-gabapentin metabolite)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Human FDA category C; teratogenic/fetotoxic effects at high doses in rodents/rabbits. Enters milk at low levels — unlikely clinically significant in veterinary patients, but data limited.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 561–564; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 349–378 (monograph pages 349–350) — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references13
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Physiological effects of a pre-anesthetic single dose of gabapentin on Xylazine/Ketamine anesthesia in rabbits.
Study summary not available in the imported record. Open the original citation to review the study.
- Acute trazodone administration reduces behavioral and physiological indicators of travel-induced anxiety in dogs in a road travel model.
Study summary not available in the imported record. Open the original citation to review the study.
- Oral use of anxiolytic, sedative, and anaesthetic medications in domestic cats (Felis catus): A scoping review.
Study summary not available in the imported record. Open the original citation to review the study.
- Reusable gelatin-based inks for 3D printing of veterinary gabapentin tablets: a sustainable approach.
Study summary not available in the imported record. Open the original citation to review the study.
- Effects of using a propofol priming and coinduction with ketamine or S(+) Ketamine on the dose of induction and duration of propofol in cats.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Perrin C, Seksel K, Landsberg GM. Appendix: Drug Dosage Chart. Vet Clin Small Anim 2014;44:629-632.; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.