MDose · Veterinary drug reference
SUCRALFATE
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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Oral/esophageal/gastric/duodenal ulcers, adjunct for NSAID-associated GI injury
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1083–1085; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 745–746 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Oral/esophageal/gastric/duodenal ulcers, adjunct for NSAID-associated GI injury — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1083–1085; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 745–746 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Oral/esophageal/gastric/duodenal ulcers, adjunct for NSAID-associated GI injury — Extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1083–1085; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 745–746 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens6
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects202
Constipation — Most common (~2% humans/dogs)
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1083–1085; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 745–746 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Vomiting — Reported
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1083–1085; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 745–746 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting344 reports
- Lethargy (see also Central nervous system depression in 'Neurological')233 reports
- Anorexia215 reports
- Diarrhoea205 reports
- Death by euthanasia189 reports
- Other abnormal test result NOS173 reports
- Elevated alanine aminotransferase (ALT)166 reports
- Elevated serum alkaline phosphatase (SAP)140 reports
- Leucocytosis NOS140 reports
- Anaemia NOS126 reports
- Weight loss119 reports
- Elevated blood urea nitrogen (BUN)115 reports
Cat
- Vomiting23 reports
- Fever18 reports
- Anorexia17 reports
- Not eating17 reports
- Weight loss17 reports
- Diarrhoea16 reports
- Death14 reports
- Hyperglycaemia14 reports
- Hypersalivation13 reports
- Lethargy (see also Central nervous system depression in Neurological)13 reports
- Dehydration12 reports
- Lethargy (see also Central nervous system depression in 'Neurological')12 reports
Monitoring1
Clinical efficacy (resolution of GI blood loss, symptom improvement)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1083–1085; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 745–746 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
None absolute
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1083–1085; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 745–746 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Use cautiously where decreased GI transit time could be harmful
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1083–1085; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 745–746 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Intact tablets may pass through the GI tract without dissolving — always crush and suspend before dosing, don't give whole tablets.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1083–1085; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 745–746 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Give on an empty stomach (1h before or 2h after feeding) and separate from other oral medications by ≥2 hours — it will bind and reduce absorption of many co-administered drugs.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1083–1085; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 745–746 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
If also using an H2-blocker, give sucralfate ~30–60 minutes after, not simultaneously.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1083–1085; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 745–746 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions2
Fluoroquinolones (enrofloxacin, ciprofloxacin), doxycycline, tetracycline — ↓ absorption via aluminum chelation — separate dosing by ≥2h
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1083–1085; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 745–746 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Digoxin, levothyroxine, warfarin, theophylline, azithromycin, ketoconazole — ↓ absorption — separate dosing
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1083–1085; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 745–746 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Bioavailability — Only 3–5% systemically absorbed — acts locally
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1083–1085; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 745–746 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Duration — Binds to ulcer site for up to 6h
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1083–1085; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 745–746 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Absorbed fraction: renal, unchanged
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1083–1085; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 745–746 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Papich canine/feline class A (probably safe). No impaired fertility/teratogenicity in high-dose rat studies. Unknown if excreted in milk, unlikely to be of concern.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1083–1085; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 745–746 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references13
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Rational use of gastroprotectants in cats: An evidence-based approach.
Study summary not available in the imported record. Open the original citation to review the study.
- Repurposing medical devices as "button" esophagostomy tubes for extended nutritional support.
Study summary not available in the imported record. Open the original citation to review the study.
- Polyphenolic profile and gastroprotective effect of Jatropha multifida Linn leaves against ethanol-induced gastric ulcer in rats: Involvement of the NLRP3/caspase-1/GSDMD pyroptotic pathway.
Study summary not available in the imported record. Open the original citation to review the study.
- Topical Use of Sucralfate in Cutaneous Wound Management: A Narrative Review with a Veterinary Perspective.
Study summary not available in the imported record. Open the original citation to review the study.
- Effect of omeprazole and sucralfate on gastrointestinal injury in a fasting/NSAID model.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.