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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications5
Induction of general anesthesia; maintenance ≤20 min (labeled, dogs); refractory status epilepticus
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Induction of general anesthesia; maintenance ≤20 min (labeled, dogs); refractory status epilepticus — Authorized (induction, dogs); extra-label for other uses
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Induction of general anesthesia; maintenance ≤20 min (labeled, dogs); refractory status epilepticus — Authorized (induction, dogs); extra-label for other uses
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Propovan™ CF (propofol) is an anesthetic injection for use in dogs and cats as follows: 1. As a single injection to provide general anesthesia for short procedures. 2. For induction and maintenance of general anesthesia using incremental doses to effect. 3. For induction of general anesthesia where maintenance is provided by inhalant anesthetics. Induction of general anesthesia will usually be observed within 30 to 60 seconds after the end of administration (administration should take 60 to 90 seconds). The doses for induction and maintenance vary depending upon species and preanesthetics. The duration of anesthesia varies depending upon species, dose, and preanesthetics. In dogs, the duration of anesthesia following the recommended induction dose (5.5 to 7.0 mg/kg without premedication) is generally 5 to 7 minutes. The duration of anesthesia after maintenance doses varies from 2 to 6 minutes following 1.1 mg/kg to 6 to 10 minutes following 3.3 mg/kg. Full standing recovery is generally observed within 10 to 20 minutes after the end of anesthesia, regardless of the duration of anesthesia. Recovery may be delayed in sighthounds or if preanesthetics are administered. In cats, the duration of anesthesia following the recommended induction dose (8.0 to 13.2 mg/kg without premedication) is generally 5 to 12 minutes. The duration of anesthesia after maintenance doses varies from 5 to 7 minutes following 1.1 mg/kg to 12 to 18 minutes following 4.4 mg/kg. Full standing recovery is generally observed within 30 to 45 minutes after the end of anesthesia, regardless of the duration of anesthesia. Recovery may be delayed if preanesthetics are administered.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34067-9 (INDICATIONS & USAGE SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
® Rapanofal(propofol) is an anesthetic injection for use in dogs and cats as follows: 1. As a single injection to provide general anesthesia for short procedures. 2. For induction and maintenance of general anesthesia using incremental doses to effect. 3. For induction of general anesthesia where maintenance is provided by inhalant anesthetics. Induction of general anesthesia will usually be observed within 30 to 60 seconds after the end of administration (administration should take 60 to 90 seconds). The doses for induction and maintenance vary depending upon species and preanesthetics. The duration of anesthesia varies depending upon species, dose, and preanesthetics. In dogs, the duration of anesthesia following the recommended induction dose (5.5 to 7.0 mg/kg without premedication) is generally 5 to 7 minutes. The duration of anesthesia after maintenance doses varies from 2 to 6 minutes following 1.1 mg/kg to 6 to 10 minutes following 3.3 mg/kg. Full standing recovery is generally observed within 10 to 20 minutes after the end of anesthesia, regardless of the duration of anesthesia. Recovery may be delayed in sighthounds or if preanesthetics are administered. In cats, the duration of anesthesia following the recommended induction dose (8.0 to 13.2 mg/kg without premedication) is generally 5 to 12 minutes. The duration of anesthesia after maintenance doses varies from 5 to 7 minutes following 1.1 mg/kg to 12 to 18 minutes following 4.4 mg/kg. Full standing recovery is generally observed within 30 to 45 minutes after the end of anesthesia, regardless of the duration of anesthesia. Recovery may be delayed if preanesthetics are administered.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34067-9 (INDICATIONS & USAGE SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
PropofolVet Multidose is an anesthetic injection for use in dogs as follows:For induction of anesthesia.For maintenance of general anesthesia by intermittent bolus injections for short procedures.For induction of general anesthesia where maintenance is provided by inhalant anesthetics.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34067-9 (INDICATIONS & USAGE SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens9
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects208
Apnea, respiratory depression — Common, dose/rate-related
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Hypotension (vasodilation) — Common
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Paddling/tremors/myoclonus during induction — 3–7% incidence
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Heinz body formation, slowed recovery, anorexia, lethargy, diarrhea — With repeated once-daily or prolonged use
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Excitement, myotonus during recovery — If used alone without other sedatives
HorseNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Death463 reports
- Vomiting307 reports
- Bradycardia294 reports
- Cardiac arrest273 reports
- INEFFECTIVE, ANESTHESIA273 reports
- Lack of efficacy - NOS231 reports
- Apnoea225 reports
- Seizure NOS180 reports
- Diarrhoea161 reports
- Lethargy (see also Central nervous system depression in 'Neurological')153 reports
- Anorexia148 reports
- Death by euthanasia143 reports
Cat
- Death153 reports
- Behavioural disorder NOS137 reports
- Not eating104 reports
- Dilated pupils102 reports
- Cardiac arrest88 reports
- Anorexia81 reports
- Hyperactivity80 reports
- Lethargy (see also Central nervous system depression in Neurological)72 reports
- Death by euthanasia71 reports
- Fever69 reports
- Dysphoria68 reports
- Apnoea64 reports
Monitoring1
Respiratory rate and character throughout anesthesia; cardiovascular status
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications4
Hypersensitivity; hypotensive patients
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Propovan™ CF injection is contraindicated in dogs and cats with a known hypersensitivity to propofol or its components, or when general anesthesia or sedation are contraindicated.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34070-3 (CONTRAINDICATIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
® Rapanofalinjection is contraindicated in dogs and cats with a known hypersensitivity to propofol or its components, or when general anesthesia or sedation are contraindicated.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34070-3 (CONTRAINDICATIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
PropofolVet Multidose is contraindicated in dogs with a known hypersensitivity to propofol or its components, or when general anesthesia or sedation are contraindicated.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34070-3 (CONTRAINDICATIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Precautions11
Shock/severe stress/trauma (more sensitive to CV/resp depression); hypoproteinemia (high protein binding); history of hyperlipidemia, seizures, anaphylaxis; cats with pre-existing liver disease (longer recovery)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Provides essentially no analgesia — always pair with a separate analgesic plan.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Repeated consecutive-day use is a known problem specifically in cats (Heinz body anemia, cumulative malaise) — appears safe for repeated use in dogs.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Good bacterial growth medium (no preservative in original formulation) — treat as single-use unless using a preserved formulation (PropoFlo 28/Plus).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Never use alone in horses — pair with other sedatives (e.g., guaifenesin) to prevent excitement/myotonus on recovery.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions6
Inhalant anesthetics (halothane, isoflurane) — ↑ propofol serum concentrations
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Anticholinergics — May exacerbate propofol-induced bradycardia, esp. with opioid premeds
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Medetomidine — Risk of hypoxemia when propofol given after — adjust dose, monitor
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metoclopramide — ↓ induction dose requirement (~20–25%, human data)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Midazolam — Synergistic — can ↑ midazolam plasma levels up to 20%
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics7
Protein binding — 95–99%
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — ~1.4h (dog)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — Hepatic glucuronide conjugation → inactive metabolites
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Renal
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
After a single dose, propofol blood level profiles are characterized by a rapid distribution phase and a rapid elimination phase. The liver is the main site of metabolism with the major portion of metabolites being excreted in urine. No change in pharmacokinetics occurs after multiple daily dosing in dogs. Concomitant medication may affect the pharmacokinetics of either propofol or other medications. In dogs, Propovan™ CF injection has been used in association with acepromazine, atropine, glycopyrrolate, halothane, isoflurane, medetomidine, oxymorphone, and xylazine. No pharmacological incompatibility has been encountered. In cats, Propovan™ CF injection has been used in association with acepromazine, atropine, glycopyrrolate, butorphanol, oxymorphone, xylazine, and halothane. No pharmacological incompatibility has been encountered. To report suspected adverse drug events, call 1-888-621-0189. To obtain a copy of the Safety Data Sheet (SDS) or for technical assistance go to www.iavoes.com. For additional information about adverse drug experience reporting for animal drugs, Contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae.
Species not recordedOn-label (ON_LABEL)United States1 source record · View provenance
- Species not recorded · SPL section 34090-1 (CLINICAL PHARMACOLOGY SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Crosses placenta; safety not established. High doses (6x) in lab animals ↑ maternal death, ↓ offspring survival. Human FDA category B. Excreted in milk — use with caution in nursing patients.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1015–1018; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 683–686 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references2
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Sedative and anesthetic-sparing effects of perioperative full-spectrum cannabis oil in female dogs undergoing unilateral mastectomy and ovariohysterectomy.
Study summary not available in the imported record. Open the original citation to review the study.
- Comparison of Four Sedation and Anaesthesia Protocols during Stress Radiography of the Coxofemoral Joint Using a Distension Device Modified for Force Measurements.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: DailyMed, U.S. National Library of Medicine; PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.
Available products
Products listed in the Health Canada Drug Product Database for this active ingredient. A listing does not establish that a product is authorized for the clinical uses described on this page.