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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Aggression, anxiety-related behaviors, obsessive-compulsive disorders
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Aggression, anxiety-related behaviors, obsessive-compulsive disorders — Extra-label (human drug)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Aggression, anxiety-related behaviors, obsessive-compulsive disorders — Extra-label (human drug)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens6
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects65
Anorexia, lethargy, GI effects, anxiety, irritability, insomnia/hyperactivity, panting — Profile not fully established
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Aggression in previously non-aggressive dogs — Possible
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Sedation, ↓appetite/anorexia, vomiting, diarrhea, elimination-pattern changes — Feline profile
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Lack of efficacy - NOS6 reports
- Decreased appetite3 reports
- Polydipsia3 reports
- Polyuria3 reports
- Seizure NOS3 reports
- Aggression2 reports
- Anorexia2 reports
- Elevated serum alkaline phosphatase (ALP)2 reports
- Hives (see also Skin)2 reports
- Medication error NOS2 reports
- Shaking2 reports
- Tachypnoea2 reports
Cat
- Dermal plaque1 reports
- Elevated renal parameters1 reports
- Haemorrhagic bladder1 reports
- Urinary tract infection1 reports
Monitoring1
Behavioral response at 6–8 weeks; appetite; sedation; GI signs
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications3
SSRI hypersensitivity; MAOIs (selegiline, amitraz)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
MAOIs, cisapride
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Table 1 (p.630), row: Sertraline, Contraindications column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
- Cat · Table 1 (p.630), row: Sertraline, Contraindications column · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Manual
Precautions4
Often chosen over fluoxetine/paroxetine for the milder interaction profile + generic price.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Geriatric/severe hepatic disease (dose adjust); seizure history
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The "6–8 weeks before judging, 3–6 months total with behavior modification" framing is the whole SSRI treatment philosophy in one dosing note: drugs open the learning window; training walks through it.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Perrin flags sertraline and fluvoxamine with cisapride interactions (CYP3A4) — a vet-specific combo risk (cisapride still compounded).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions4
MAOIs — Serotonin syndrome — contraindicated
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Tramadol, trazodone, serotonergics — Serotonin syndrome risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
NSAIDs/anticoagulants — Bleeding risk (platelet effect)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
CYP substrates — Fewer than paroxetine but present
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Mechanism — SSRI (less CYP-inhibiting than paroxetine/fluoxetine)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — Hepatic — adjust in severe hepatic disease/geriatrics
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Generic availability — Inexpensive generics
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Avoid (class caution).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1056–1057; Perrin C, Seksel K, Landsberg GM. Drug dosage chart. Vet Clin Small Anim 2014;44:629–632 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references17
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Effects of Exercise Type and Sertraline on Anxiety and Social Behavior in a Female Rat Model of PTSD.
Study summary not available in the imported record. Open the original citation to review the study.
- A narrative review on the environmental impact of medicines: from water analysis and in vivo studies to prescribing appropriateness, based on European and Italian legal frameworks.
Study summary not available in the imported record. Open the original citation to review the study.
- Nepetin attenuates sertraline-induced cardiac dysfunction by modulating notch signaling, oxidative stress, and inflammation: Echocardiographic and histological evidence.
Study summary not available in the imported record. Open the original citation to review the study.
- Biofilm formation on polyethylene microplastics and their role as transfer vector of emerging organic pollutants.
Study summary not available in the imported record. Open the original citation to review the study.
- Severe hypercalcemia caused by repeated mineral oil injections: a case report.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Perrin C, Seksel K, Landsberg GM. Appendix: Drug Dosage Chart. Vet Clin Small Anim 2014;44:629-632.; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.