MDose · Veterinary drug reference
PENICILLIN G
Favorites and recent references stay on this device. No patient data is stored.
Choose the species
One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
Choose one species for its overview and dose calculator, or all species to browse the full evidence.
Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications5
Susceptible gram-positive/anaerobic/spirochete infections (IV route for serious)
CatDogExtra-label (EXTRA_LABEL)2 source records · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Susceptible gram-positive/anaerobic/spirochete infections (IV route for serious) — Extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Susceptible gram-positive/anaerobic/spirochete infections (IV route for serious) — Extra-label
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Gram-positive aerobes/anaerobes; tetanus, botulism, strangles, foal C. difficile; general susceptible infections
HorseExtra-label (EXTRA_LABEL)1 source record · View provenance
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Gram-positive aerobes/anaerobes; tetanus, botulism, strangles, foal C. difficile; general susceptible infections — Extra-label/label (formulation-dependent)
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Susceptible infections (procaine/combo products, label with withdrawals)
CattleSwineOn-label (ON_LABEL)2 source records · View provenance
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Susceptible infections (procaine/combo products, label with withdrawals) — Authorized (label)
- Swine · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Susceptible infections (procaine/combo products, label with withdrawals) — Authorized (label)
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens8
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects205
Hypersensitivity — Class risk
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
CNS effects at very high doses (seizures) — Overdose
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Procaine reactions: excitement, ataxia, collapse (idiosyncratic) — Formulation-specific
HorseAvianNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Avian · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
IM injection pain (procaine) — Route effect
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Injection site abscess39 reports
- Injection site swelling30 reports
- Vomiting27 reports
- Death25 reports
- Anorexia13 reports
- Injection site necrosis12 reports
- Convulsion10 reports
- Death by euthanasia10 reports
- Elevated alanine aminotransferase (ALT)10 reports
- Fever10 reports
- Injection site pain10 reports
- Anaphylaxis9 reports
Cat
- Death14 reports
- Dyspnoea9 reports
- Anaphylaxis8 reports
- Hypersalivation8 reports
- Anorexia7 reports
- Vomiting7 reports
- Hypothermia5 reports
- Respiratory distress5 reports
- Vocalisation5 reports
- Ataxia4 reports
- Cardiac arrest4 reports
- Convulsion4 reports
Monitoring1
Clinical efficacy; procaine-reaction watch post-IM (horses); renal/K considerations with massive aqueous dosing
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Penicillin hypersensitivity (unless no alternative)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions5
K-salt IV rate in renal/heart failure (potassium load); food-animal withdrawal per product label
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The strangles rule is pure clinical judgment: fever-only early = treat; breathing-well lymphadenopathy = don't (abscess maturation is immunology's job); depressed/dyspneic = treat hard.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Formulation = prescription: aqueous for sepsis-level peaks, procaine for practical q12h coverage, benzathine ONLY when low-level-days-long suffices (it never achieves MIC against moderately sensitive bugs).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The procaine-reaction story (snorting, circling horse after injection) is the classic barn-call trivia — distinguish from anaphylaxis.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The "if still susceptible, prefer the natural penicillin" principle: narrows spectrum, preserves the newer drugs.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions3
Aminoglycosides — Synergy (deliberate) — separate administration
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Bacteriostatics (tetracycline/chloramphenicol class) — Antagonism theoretical
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Probenecid — ↑ levels
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Mechanism — Cell-wall mucopeptide synthesis inhibition → osmotically unstable spheroplast (bactericidal)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Formulation logic — Aqueous K/Na = high peaks q6h; procaine = depot q12–24h (painful); benzathine = days-long low levels (sensitive organisms only); combo = immediate + sustained
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Procaine sensitivity — Certain species (horses idiosyncratic; small birds) react to procaine itself — excitement/ataxia
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Penicillin class = safest-in-pregnancy standard.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 944–947 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references12
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Evaluation of ß-lactamase-induced inactivation of penicillin G and cefoperazone in spiked ultra-high temperature and raw unpasteurized milk.
Study summary not available in the imported record. Open the original citation to review the study.
- A natural probioenzyme strategy as an effective alternative to antibiotics against multidrug-resistant Klebsiella pneumoniae in broilers: Benefits for growth, immunity, and organ health.
Study summary not available in the imported record. Open the original citation to review the study.
- Characterization of Staphylococci colonizing healthy equine skin: antibiotic resistance, virulence factors, and biofilm formation.
Study summary not available in the imported record. Open the original citation to review the study.
- Anchoring MoO(3) on Magnetic Nickel Ferrite: A Sustainable Green Nanocatalyst in Conjunction With UV Light Irradiation Toward Efficient Degradation of Penicillin G in Water Environments.
Study summary not available in the imported record. Open the original citation to review the study.
- Escherichia coli O157:H7 prevalence in Upper Egypt: impacts on food safety and human Health, with a protection trial using natural antibacterial Piper cubeba.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.