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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Generalized demodicosis (dips — Mitaban label); flea/tick prevention (spot-on/collar); sarcoptic mange
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Generalized demodicosis (dips — Mitaban label); flea/tick prevention (spot-on/collar); sarcoptic mange — Authorized (label uses); extra-label protocols
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Not safe (CNS sensitivity)
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Not safe (CNS sensitivity) — Avoid
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens4
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects124
Transient sedation (alpha2) — call vet if unarousable >72 h — Common post-dip
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Lethargy, ataxia, bradycardia, vomiting; hypothermia — Alpha2 cascade
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Hyperglycemia — Insulin inhibition
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Skin reactions — Possible
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
No stress/exercise for 24 h post-dip — Label instruction
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Lethargy (see also Central nervous system depression in 'Neurological')341 reports
- Depression278 reports
- Vomiting234 reports
- Ataxia134 reports
- Anorexia101 reports
- Diarrhoea94 reports
- Death85 reports
- Lack of efficacy (ectoparasite) - Demodex83 reports
- Sedation66 reports
- Pruritus61 reports
- Convulsion55 reports
- Behavioural disorder NOS52 reports
Cat
- Ataxia3 reports
- Abnormal radiograph finding2 reports
- Dehydration2 reports
- Vomiting2 reports
- Abnormal breathing1 reports
- Anorexia1 reports
- Bradycardia1 reports
- Cardiac enlargement1 reports
- Constipation1 reports
- Depression1 reports
- Dyspnoea1 reports
- Hypothermia1 reports
Monitoring1
Skin scrapes q2–4 wk (two consecutive negative + 30 days = cure line); sedation level post-dip (un-arousable >72 h = vet call); glucose in diabetics
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Other MAO inhibitors (selegiline, amitraz-interaction drugs) — serotonin-syndrome-class risk; diabetic patients (hyperglycemia); <4 months old; cats
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Toy-breed CNS sensitivity; owner pregnullness/human exposure precautions (gloves/vapors)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Amitraz is a drug wearing a pesticide costume: alpha2 agonism means atipamezole reverses its toxicity — the same antidote logic as dexmedetomidine. Sedation after a dip = expected alpha2 pharmacology.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The dip rules ARE the prescription: air-dry (no rinse/towel), fresh dilution, no stress 24 h, treat past 2 negative scrapes.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
MAO-inhibitor interactions (selegiline!) make the medication-history check mandatory before dipping a dog on behavioral/Cushing's drugs.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions4
MAOIs (selegiline) — Contraindicated — combined MAO inhibition toxicity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
SSRIs/TCAs (mirtazapine-era note) — Serotonin-syndrome risk class (Plumb flags mirtazapine + amitraz)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Insulin/diabetic drugs — Hyperglycemia antagonizes control
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Atipamezole/yohimbine — The antidotes (alpha2 reversal — see atipamezole.md)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Mechanism — MAO inhibitor (in mites) + alpha2-adrenergic agonist activity — the alpha2 piece explains the toxicity profile
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolic effect — Hyperglycemia (alpha2 inhibits insulin release) — diabetics caution
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Rule-of-thumb duration — Treat 30 days past TWO consecutive negative skin scrapes
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Not established; toy breeds and <4 months more susceptible (label excludes).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 1241–1242 (topical appendix) — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references20
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Effective treatment with afoxolaner (NexGard) of Trixacarus caviae in a pet guinea pig.
Study summary not available in the imported record. Open the original citation to review the study.
- Drivers and evolution of acaricide resistance and multi-resistance in two Ecuador's subtropical livestock farming areas.
Study summary not available in the imported record. Open the original citation to review the study.
- Improving Apis mellifera iberiensis colony development through a combined spring oxalic acid and autumn amitraz treatment for varroosis control.
Study summary not available in the imported record. Open the original citation to review the study.
- Drugs and products in beekeeping: Efficacy and perspectives of natural alternatives.
Study summary not available in the imported record. Open the original citation to review the study.
- Clinical therapeutic management of camel mange: a case report.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.