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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
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View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Dose regimens1
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects115
Hypercalcemia (→ GFR loss), soft-tissue mineralization (if P high)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Lethargy (see also Central nervous system depression in 'Neurological')6 reports
- Emesis3 reports
- Seizure NOS3 reports
- Ataxia2 reports
- Death2 reports
- Diarrhoea2 reports
- Inappetence2 reports
- Other abnormal test result NOS2 reports
- Vomiting2 reports
- Bloody diarrhoea1 reports
- Abdominal discomfort1 reports
- Abdominal effusion1 reports
Cat
- Behavioural disorder NOS4 reports
- Death4 reports
- Lack of efficacy - NOS4 reports
- Weight loss4 reports
- Death by euthanasia3 reports
- Elevated creatinine3 reports
- Regurgitation3 reports
- Diarrhoea2 reports
- Hind limb ataxia2 reports
- Hypersalivation2 reports
- Intentional misuse2 reports
- Ketosis2 reports
Interactions1
Calcium-based phosphate binders (hypercalcemia stacking)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 573–574 (glipizide), p. 180–181 (calcitriol), p. 770–772 (megestrol) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references20
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Metabolic and reproductive responses to calcium propionate and 1,25-dihydroxyvitamin D3 in transition dairy cows.
Study summary not available in the imported record. Open the original citation to review the study.
- Effect of dietary Ca:P ratio on ionized calcium and calcium homeostasis in cats with early-stage chronic kidney disease.
Study summary not available in the imported record. Open the original citation to review the study.
- Preoperative parathyroid hormone concentration predicts postoperative hypocalcemia severity in dogs undergoing parathyroidectomy.
Study summary not available in the imported record. Open the original citation to review the study.
- Vitamin D(3) Metabolite-Enhanced Hepatic VDR-FXR Binding Attenuates Bile Acid Dysregulation-Induced Diarrhea in Weaned Piglets.
Study summary not available in the imported record. Open the original citation to review the study.
- Effect of 25-OH-cholecalciferol supplementation on acute phase reactants, cytokines, and colostrum quality of Holstein cows during the transition period and plasma metabolites of newborn calves.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.