MDose · Veterinary drug reference
OXYTETRACYCLINE
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One selection filters the source overview, clinical facts, reports and dose calculator. Literature references are not species-filtered.
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Source overview
Recorded excerpts for one species. Each dose remains a separate source entry; no regimen is selected.
Choose one species to view its source overview. All-species evidence remains available below.
View full clinical evidence and sources ↓Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications4
Ehrlichiosis/anaplasmosis (drug of choice), Potomac Horse Fever, Lyme, foal Lawsonia proliferative enteropathy; susceptible infections
HorseExtra-label (EXTRA_LABEL)1 source record · View provenance
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Ehrlichiosis/anaplasmosis (drug of choice), Potomac Horse Fever, Lyme, foal Lawsonia proliferative enteropathy; susceptible infections — Extra-label/label
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Anaplasmosis (control + carrier-state clearance), BRD, anthrax
CattleOn-label (ON_LABEL)1 source record · View provenance
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Anaplasmosis (control + carrier-state clearance), BRD, anthrax — Authorized (label products)
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Enteritis/pneumonia, pregnant-ewe campylobacteriosis outbreaks
Sheep / goatExtra-label (EXTRA_LABEL)1 source record · View provenance
- Sheep / goat · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Enteritis/pneumonia, pregnant-ewe campylobacteriosis outbreaks — Authorized/extra-label
- Sheep / goat · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Legacy — doxycycline/minocycline preferred
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Legacy — doxycycline/minocycline preferred — Legacy
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Indications table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens10
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Choose one species above to view its dose calculator.
Adverse effects204
Collapse/arrhythmias on rapid IV — Rate-related (cattle esp.)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
IM tissue injury — Site-discipline related
CattleSwineNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Cattle · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Swine · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Renal injury (esp. foals/dehydration) — Monitor creatinine
HorseNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsCat
- Vomiting43 reports
- Eyelid oedema23 reports
- Conjunctivitis20 reports
- Anaphylaxis18 reports
- Diarrhoea17 reports
- Lethargy (see also Central nervous system depression in 'Neurological')17 reports
- Anorexia16 reports
- Eye irritation15 reports
- Eye redness15 reports
- Lack of efficacy (bacteria) - NOS13 reports
- Death12 reports
- Lack of efficacy - NOS12 reports
Dog
- Injection site pain14 reports
- Injection site swelling14 reports
- Corneal ulcer10 reports
- Vomiting10 reports
- Anorexia9 reports
- Fever8 reports
- Depression7 reports
- Eye pain6 reports
- Ocular discharge6 reports
- Blepharospasm5 reports
- Corneal disorder NOS5 reports
- Diarrhoea5 reports
Monitoring1
Renal values (foals), injection sites, IV administration rate discipline
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions5
Renal insufficiency; do not use in recently anthrax-vaccinated healthy animals (negates vaccine); young/pregnant (class)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The Rickettsia-family drug of horses: anaplasmosis/PHF/Lyme at 6.6 mg/kg diluted-slow — the dilution-and-rate rule IS the safety profile (tremors→collapse when rushed).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Anaplasmosis double life: vector-season depot control (LA-200 q3–4 wk) vs carrier-clearance pulse (22 mg/kg × 5 d) — different jobs, different regimens.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Foal Lawsonia sequence (oxytet IV → doxycycline PO) shows the class relay logic — IV potency then oral maintenance.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
The contracted-foal-tendon MMP trick (massive-dose laxity) is famous but lives in the older literature — know it as pharmacology trivia, verify against current sources before use.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions3
Warfarin — Effect ↑ (class)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Oral cations (Ca/Mg/Fe/Al — milk/dairy) — Chelation — separate
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Antacids/sucralfate class — Absorption ↓
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics3
Mechanism — 30S ribosome class; unique horse effect: MMP-9 inhibition (flexor-tendon laxity exploitation in contracted foals — the famous 1–3 g IV once trick of the pre-Plumb era literature)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
LA-200 depot — Slow IM absorption → days-long low levels (label q72h cattle)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Vd — 2.1 L/kg (small animals); 1.4 (horse); 0.8 (cattle)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Tetracycline class: tooth/bone fetal effects — avoid where possible.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 922–927 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references10
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Prevalence, serotype diversity, and antibiotic resistance of non-typhoidal Salmonella in East African poultry: A systematic review and meta-analysis.
Study summary not available in the imported record. Open the original citation to review the study.
- Survey of Smallholder Dairy Cattle Farming System and Antibiotic Residues in Raw Cow's Milk in Bagamoyo District, Tanzania.
Study summary not available in the imported record. Open the original citation to review the study.
- A Comparative Multi-Bioassay Assessment of Tetracycline Mixture Toxicity in Water and Soil Using Harmonized Dose-Response Modeling.
Study summary not available in the imported record. Open the original citation to review the study.
- Phytotoxic effects and rhizosphere microecological responses of peanut to oxytetracycline and microplastic co-exposure.
Study summary not available in the imported record. Open the original citation to review the study.
- MIC and MBC of silver nanoparticles in antibiotic-resistant Salmonella sp. from dairy cattle waste.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.