Regulatory product record
SALIX
Product identity, ingredients and source provenance from the regulatory catalogue. Linked clinical evidence has a separate review status.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.
Product identity
- Brand name
- SALIX
- DIN
- 00116238
- DPD drug code
- 6884
- Regulatory category
- APPROVED_VET_DRUG
- Market status
- MARKETED
- Route(s)
- INTRAMUSCULAR, INTRAVENOUS
- Pharmaceutical form(s)
- SOLUTION
- Ingredients
- FUROSEMIDE (50 MG)
- Species (DPD record)
- DOGS, CATS
- Company
- INTERVET CANADA CORP (DIN owner)
Source and provenance
- Source dataset
- health_canada_dpd_marketed
- Source snapshot date
- Not available in this source
- Source record key
- 6884
- Archive fingerprint (SHA-256)
- 85cc3ce208af3aa57018c3d14d83f90220c436baef7455384b6d48d9774e1c88
Linked clinical reference
Clinical entries are linked through the active molecule. Check their species, formulation, source and review status separately from this product record.
Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications2
Pulmonary edema, CHF, hypercalcemia, hyperkalemia (adjunct), oliguric renal failure
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Pulmonary edema, CHF, hypercalcemia, hyperkalemia (adjunct), oliguric renal failure — Extra-label (no vet-specific FDA small-animal product)
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Pulmonary edema, CHF, hypercalcemia, hyperkalemia (adjunct), oliguric renal failure — Extra-label (no vet-specific FDA small-animal product)
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens8
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Select a species above to calculate a dose.
Adverse effects205
Ototoxicity — High-dose IV, especially cats
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Hyponatremia (more so than hypokalemia in dogs), dehydration — Common with chronic use
DogCatNot applicable (NOT_APPLICABLE)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
RAAS activation with repeated dosing → tolerance/attenuated effect — Documented (by day 5 at 2 mg/kg q12h)
DogNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pre-renal azotemia — If dehydration occurs
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Vomiting248 reports
- Lethargy (see also Central nervous system depression in 'Neurological')213 reports
- Death by euthanasia195 reports
- Diarrhoea195 reports
- Death188 reports
- Seizure NOS135 reports
- Anorexia127 reports
- Cough126 reports
- Elevated blood urea nitrogen (BUN)123 reports
- Abnormal radiograph finding93 reports
- Weight loss87 reports
- Lack of efficacy - NOS84 reports
Cat
- Death by euthanasia57 reports
- Death52 reports
- Vomiting45 reports
- Anorexia44 reports
- Abnormal radiograph finding43 reports
- Lethargy (see also Central nervous system depression in 'Neurological')39 reports
- Pulmonary oedema35 reports
- Dyspnoea33 reports
- Weight loss33 reports
- Other abnormal test result NOS30 reports
- Lethargy (see also Central nervous system depression in Neurological)26 reports
- Tachypnoea26 reports
Monitoring1
Serum electrolytes (esp. sodium, potassium), BUN/creatinine, hydration status, respiratory rate at home (owner-tracked sleeping RR)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Contraindications1
Anuria; hypersensitivity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions4
Pre-existing electrolyte/water imbalance, hepatic impairment (may precipitate hepatic coma), diabetes mellitus; possible sulfonamide cross-sensitivity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Goal is always the "lowest effective dose" — titrate to clinical signs (respiratory rate/effort), not a fixed target dose; give owners a dose range with instructions to adjust based on breathing vs. lethargy.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cats are more sensitive to both the diuretic and ototoxic effects of furosemide than dogs.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Chronic use activates RAAS, which is why furosemide is almost always combined with an ACE inhibitor ± spironolactone in CHF management, not used alone long-term.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions5
ACE inhibitors — ↑ hypotension risk, especially if volume-depleted
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Aminoglycosides, amphotericin B — ↑ ototoxicity/nephrotoxicity risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Digoxin — Furosemide-induced hypokalemia → ↑ digoxin toxicity risk
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
NSAIDs — ↓ diuretic effect
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Corticosteroids — ↑ GI ulceration risk, ↑ hypokalemia
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics5
Bioavailability — ~77% PO (dog)
HorseNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Horse · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Protein binding — ~95% (human data)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — 1–1.5h (dog); short (1.5–3h general)
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Metabolism — Minimal
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Elimination — Renal
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Papich canine/feline class B. Excreted in milk, clinical significance unknown.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 558–560; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 346–348 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references17
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Rare stability in dogs with myxomatous mitral valve disease: Clinical observations of loop diuretic withdrawal after congestive heart failure.
Study summary not available in the imported record. Open the original citation to review the study.
- Urine sodium concentration and diuretic responsiveness in dogs receiving orally administered loop diuretics for chronic congestive heart failure.
Study summary not available in the imported record. Open the original citation to review the study.
- Clinical findings and survival time in dogs with myxomatous mitral valve disease at the American College of Veterinary Internal Medicine stage D.
Study summary not available in the imported record. Open the original citation to review the study.
- Furosemide Administration Enhances Diagnostic Confidence in the Evaluation of Ureteral Ectopia in Dogs Using Ultrasound.
Study summary not available in the imported record. Open the original citation to review the study.
- Serum chloride and the response to hydrochlorothiazide in patients with acute heart failure: a post-hoc analysis from the CLOROTIC trial.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.