METACAM ORAL SUSPENSION

• OA pain/inflammation (chronic)

  DogOn-label (ON_LABEL)
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  • Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based

    Original excerpt: OA pain/inflammation (chronic) — Authorized

• Single-dose post-op pain (ovariohysterectomy, orthopedic, castration)

  CatOn-label (ON_LABEL)
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  • Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Indications table · Not applicable · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based

    Original excerpt: Single-dose post-op pain (ovariohysterectomy, orthopedic, castration) — Authorized (FDA, single SC dose)

• Chronic low-dose use for OA/CKD pain

  CatExtra-label (EXTRA_LABEL)
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  • Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based

    Original excerpt: Chronic low-dose use for OA/CKD pain — Extra-label in US (licensed long-term in some other countries)

• Meloxicam oral suspension is indicated for the control of pain and inflammation associated with osteoarthritis in dogs.

  Species not recordedOn-label (ON_LABEL)United States
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  • Species not recorded · SPL section 34067-9 (INDICATIONS & USAGE SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based

• OstiLox (meloxicam) Oral Suspension is indicated for the control of pain and inflammation associated with osteoarthritis in dogs.

  DogOn-label (ON_LABEL)United States
  1 source record · View provenance

  • Dog · SPL section 34067-9 (INDICATIONS & USAGE SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based

This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.

• GI (vomiting, diarrhea, ulceration) — Most common

  DogCatNot applicable (NOT_APPLICABLE)
  2 source records · View provenance

  • Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
  • Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based

• Renal injury — Reported at ≥0.3–0.5 mg/kg and higher (dog); with repeated/dehydrated dosing (cat)

  DogCatNot applicable (NOT_APPLICABLE)
  2 source records · View provenance

  • Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
  • Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based

• Elevated liver enzymes, pruritus, azotemia — Post-approval reports

  DogNot applicable (NOT_APPLICABLE)
  1 source record · View provenance

  • Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based

• Field safety was evaluated in 306 dogs. Based on the results of two studies, GI abnormalities (vomiting,soft stools, diarrhea, and inappetence) were the most common adverse reactions associated with the administration ofmeloxicam. The following table lists adverse reactions and the numbers of dogs that experienced them during the studies.Dogs may have experienced more than one episode of the adverse reaction during the study. In foreign suspected adverse drug reaction (SADR) reporting over a 9 year period, incidences of adverse reactions related tomeloxicam administration included: auto-immune hemolytic anemia (1 dog), thrombocytopenia (1 dog), polyarthritis (1 dog),nursing puppy lethargy (1 dog), and pyoderma (1 dog). Adverse Reactions Observed During Two Field Studies Clinical Observation Meloxicam (n=157) Placebo (n=149) Vomiting 40 23 Diarrhea/Soft Stool 19 11 Bloody Stool 1 0 Inappetence 5 1 Bleeding gums after dental procedure 1 0 Lethargy/Swollen Carpus 1 0 Epiphora 1 0

  DogOn-label (ON_LABEL)United States
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  • Dog · SPL section 34084-4 (ADVERSE REACTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based

• Field safety was evaluated in 306 dogs. Based on the results of two studies, GI abnormalities (vomiting, soft stools, diarrhea, and inappetance) were the most common adverse reactions associated with the administration of meloxicam. The following table lists adverse reactions and the numbers of dogs that experienced them during the studies. Dogs may have experienced more than one episode of the adverse reaction during the study. In foreign suspected adverse drug reaction (SADR) reporting over a 9 year period, incidences of adverse reactions related to meloxicam administration included: auto-immune hemolytic anemia (1 dog), thrombocytopenia (1 dog), polyarthritis (1 dog), nursing puppy lethargy (1 dog), and pyoderma (1 dog). Adverse Reactions Observed During Two Field Studies Clinical Observation Meloxicam(n=157) Placebo(n=149) Vomiting 40 23 Diarrhea/Soft Stool 19 11 Bloody Stool 1 0 Inappetance 5 1 Bleeding gums after dental procedure 1 0 Lethargy/Swollen Carpus 1 0 Epiphora 1 0

  Species not recordedOn-label (ON_LABEL)United States
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  • Species not recorded · SPL section 34084-4 (ADVERSE REACTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based

• Clinical efficacy, adverse effects; renal + hepatic function if chronic use (esp. cats)

  Species not recordedNot applicable (NOT_APPLICABLE)
  1 source record · View provenance

  • Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based

• Hypersensitivity; repeated dosing in cats — FDA black-box-style warning: associated with acute renal failure and death

  Species not recordedNot applicable (NOT_APPLICABLE)
  1 source record · View provenance

  • Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based

• Repeated use of meloxicam in cats has been associated with acute renal failure and death. Do not administer additional injectable or oral meloxicam to cats. See Contraindications, Warnings, and Precautions for detailed information.

  DogOn-label (ON_LABEL)United States
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  • Dog · SPL section 34066-1 (BOXED WARNING SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based

• Contraindications Warnings Precautions Repeated use of meloxicam in cats has been associated with acute renal failure and death. Do not administer additional injectable or oral meloxicam to cats. See,, andfor detailed information.

  Species not recordedOn-label (ON_LABEL)United States
  1 source record · View provenance

  • Species not recorded · SPL section 34066-1 (BOXED WARNING SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based

• Do not use Meloxicam oral suspension in cats. Acute renal failure and death have been associated with the use of meloxicam in cats. Dogs with known hypersensitivity to meloxicam should not receive Meloxicam oral suspension. Shake bottle well. Push down and unscrew bottle top. Attach the dosing syringe to the bottle by gently pushing onto the top of the bottle. Turn the bottle/syringe upside down. Pull the plunger out until the medication level corresponds to the dog's body weight in pounds. Turn the bottle right way up and with a twisting movement separate the dosing syringe from the bottle. Push the plunger to empty the contents of the syringe.

  Species not recordedOn-label (ON_LABEL)United States
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  • Species not recorded · SPL section 34070-3 (CONTRAINDICATIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based

• Dogs <6 months, cats <4 months; hepatic/cardiac/renal impairment; dehydration/hypovolemia/hypotension; 5–7 day washout recommended before switching NSAIDs in dogs

  Species not recordedNot applicable (NOT_APPLICABLE)
  1 source record · View provenance

  • Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based

• Never give a second injectable/oral dose to a cat under the US label — this is an explicit FDA/manufacturer warning after post-marketing renal failure/death reports, though low-dose chronic use is accepted practice in feline medicine outside the US label and per ISFM/AAFP consensus guidelines.

  Species not recordedNot applicable (NOT_APPLICABLE)
  1 source record · View provenance

  • Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based

• Oral liquid dosed by "drops" — concentration per drop varies by country/product; measure carefully, don't confuse dropper markings with mL/kg.

  Species not recordedNot applicable (NOT_APPLICABLE)
  1 source record · View provenance

  • Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based

• For oral use in dogs only. Not for use in humans. Keep this and all medications out of reach of children. Consult a physician in case of accidental ingestion by humans. As with any NSAID all dogs should undergo a thorough history and physical examination before the initiation of NSAID therapy. Appropriate laboratory testing to establish hematological and serum biochemical baseline data is recommended prior to and periodically during administration. Owner should be advised to observe their dog for signs of potential drug toxicity and begiven a client information sheet about OstiLox (meloxicam) Oral Suspension. Keep OstiLox (meloxicam) Oral Suspension in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose.

  DogOn-label (ON_LABEL)United States
  1 source record · View provenance

  • Dog · SPL section 34071-1 (WARNINGS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based

• The safe use of OstiLox (meloxicam) Oral Suspensionin dogs younger than 6 months of age, dogs used for breeding, or in pregnant or lactating dogs has not been evaluated. Meloxicam is not recommended for use in dogs with bleeding disorders, as safety has not been established in dogs with these disorders. As a class, cyclo-oxygenase inhibitory NSAIDs may be associated with gastrointestinal, renal and hepatic toxicity. Sensitivity to drug-associated adverse events varies with the individual patient. Dogs that have experienced adverse reactions from one NSAID may experience adverse reactions from another NSAID. Patients at greatest risk for renal toxicity are those that are dehydrated, on concomitant diuretic therapy, orthose with existing renal, cardiovascular, and/or hepatic dysfunction. Concurrent administration of potentially nephrotoxic drugs should be carefully approached. NSAIDs may inhibit the prostaglandins that maintain normal homeostatic function. Such anti-prostaglandin effects may result in clinically significant disease in patients with underlying or pre-existing disease that has not been previously diagnosed. Since NSAIDs possess the potential to induce gastrointestinal ulcerations and/or perforations, concomitant use with other anti-inflammatory drugs, such as NSAIDs or corticosteroids, should be avoided. If additional pain medication is needed after administration of the total daily dose of OstiLox (meloxicam) Oral Suspension, a non-NSAID or non-corticosteroid class of analgesia should be considered. The use of another NSAID is not recommended. Consider appropriate washout times when switching from corticosteroid use or from one NSAID to another in dogs. The use of concomitantly protein-bound drugs with OstiLox (meloxicam) Oral Suspensionhas not been studied in dogs. Commonly used protein-bound drugs include cardiac, anticonvulsant and behavioral medications. The influence of concomitant drugs that may inhibit metabolism of OstiLox (meloxicam) Oral Suspension has not been evaluated. Drug compatibility should be monitored in patients requiring adjunctive therapy.

  DogOn-label (ON_LABEL)United States
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  • Dog · SPL section 42232-9 (PRECAUTIONS SECTION) · United States · On-label (ON_LABEL) · Pending clinical review (PROPOSED) · Rule-based

• ACE inhibitors — ↓ antihypertensive effect

  Species not recordedNot applicable (NOT_APPLICABLE)
  1 source record · View provenance

  • Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based

• Anticoagulants — ↑ bleeding risk

  Species not recordedNot applicable (NOT_APPLICABLE)
  1 source record · View provenance

  • Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based

• Aspirin, corticosteroids, other NSAIDs — ↑ GI toxicity

  Species not recordedNot applicable (NOT_APPLICABLE)
  1 source record · View provenance

  • Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based

• Digoxin — ↑ digoxin levels

  Species not recordedNot applicable (NOT_APPLICABLE)
  1 source record · View provenance

  • Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based

• Fluconazole — Possible ↑ meloxicam levels

  Species not recordedNot applicable (NOT_APPLICABLE)
  1 source record · View provenance

  • Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based

• Bioavailability — Near-complete PO with food (dog); 85–98% (horse)

  Species not recordedNot applicable (NOT_APPLICABLE)
  1 source record · View provenance

  • Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based

• Protein binding — ~97%

  DogCatNot applicable (NOT_APPLICABLE)
  2 source records · View provenance

  • Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
  • Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based

• Half-life — 24h avg (12–36h range, dog); 15–26h (cat, study-dependent); 8.5h (horse)

  DogNot applicable (NOT_APPLICABLE)
  1 source record · View provenance

  • Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based

• Metabolism — Extensive hepatic, multiple inactive metabolites

  Other speciesNot applicable (NOT_APPLICABLE)
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  • Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based

• Elimination — Primarily fecal

  Species not recordedNot applicable (NOT_APPLICABLE)
  1 source record · View provenance

  • Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based

• Not established in breeding/pregnant/lactating dogs or cats. Human FDA category C. Most NSAIDs excreted in milk — use cautiously.

  Species not recordedNot applicable (NOT_APPLICABLE)
  1 source record · View provenance

  • Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 779–782; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 488–518 (monograph pages 488–490) — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based

References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.

• First UV-Based Strategies Integrating Whiteness, Greenness, and Blueness Appraisals for Estimating Meloxicam and Tramadol Concurrently in Their Veterinary Mixture.Archiv der Pharmazie · PMID: 42635191Imported publication date: 2026-08-01Study type not classified in this record

  Study summary not available in the imported record. Open the original citation to review the study.

• Meloxicam blood levels are not affected by sex-related hormones in male and female goats.Veterinarni medicina · PMID: 42494377Imported publication date: 2026-06-01Study type not classified in this record

  Study summary not available in the imported record. Open the original citation to review the study.

• Use of non-steroidal anti-inflammatory drugs for Finnish sows.Preventive veterinary medicine · PMID: 42435675Imported publication date: 2026-07-10Study type not classified in this record

  Study summary not available in the imported record. Open the original citation to review the study.

• Perioperative analgesia and clinical safety of dexketoprofen in dogs undergoing ovariohysterectomy.Open veterinary journal · PMID: 42375982Imported publication date: 2026-04-01Study type not classified in this record

  Study summary not available in the imported record. Open the original citation to review the study.

• The Use of Doramectin Reduces Respiratory Mite Associated Mortality in a Population of Gouldian Finches (Chloebia gouldiae).Journal of avian medicine and surgery · PMID: 42301998Imported publication date: 2026-06-01Study type not classified in this record

  Study summary not available in the imported record. Open the original citation to review the study.