Regulatory product record
MOMETAMAX
Product identity, ingredients and source provenance from the regulatory catalogue. Linked clinical evidence has a separate review status.
Owner information handout
Plain-language medication information to review with the owner. Open the handout to print it or download a PDF.
Product identity
- Brand name
- MOMETAMAX
- DIN
- 02344688
- DPD drug code
- 83017
- Regulatory category
- APPROVED_VET_DRUG
- Market status
- MARKETED
- Route(s)
- OTIC
- Pharmaceutical form(s)
- SUSPENSION
- Ingredients
- GENTAMICIN (GENTAMICIN SULFATE) (3 MG), CLOTRIMAZOLE (10 MG), MOMETASONE FUROATE (MOMETASONE FUROATE MONOHYDRATE) (1 MG)
- Species (DPD record)
- DOGS
- Company
- INTERVET CANADA CORP (DIN owner)
Source and provenance
- Source dataset
- health_canada_dpd_marketed
- Source snapshot date
- Not available in this source
- Source record key
- 83017
- Archive fingerprint (SHA-256)
- 85cc3ce208af3aa57018c3d14d83f90220c436baef7455384b6d48d9774e1c88
Linked clinical reference
Clinical entries are linked through the active molecule. Check their species, formulation, source and review status separately from this product record.
Clinical evidence
Pending clinical review (PROPOSED)Rule-based (RULE_BASED)— applies to the facts and dose entries in this species selection; individual source records retain their own status.
Indications3
Serious gram-negative aerobic infections / staphylococci when safer drugs lack susceptibility or empiric coverage is urgent (sepsis, soft tissue/orthopedic, bacteremia)
DogCatExtra-label (EXTRA_LABEL)2 source records · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Serious gram-negative aerobic infections / staphylococci when safer drugs lack susceptibility or empiric coverage is urgent (sepsis, soft tissue/orthopedic, bacteremia) — FDA-approved parenteral (dogs/cats); often extra-label by regimen
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Serious gram-negative aerobic infections / staphylococci when safer drugs lack susceptibility or empiric coverage is urgent (sepsis, soft tissue/orthopedic, bacteremia) — FDA-approved parenteral (dogs/cats); often extra-label by regimen
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Brucellosis combination protocol (with minocycline/doxycycline)
DogExtra-label (EXTRA_LABEL)1 source record · View provenance
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Original excerpt: Brucellosis combination protocol (with minocycline/doxycycline) — Extra-label
- Dog · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Indications table · Not applicable · Extra-label (EXTRA_LABEL) · Pending clinical review (PROPOSED) · Rule-based
Dose regimens6
This calculator performs arithmetic only on the sourced dosing field shown for each result — it does not verify the field's accuracy, does not select which field to use for a patient, and does not replace a veterinarian's order. Not for clinical use. Confirm every result against the primary source before dispensing.
Select a species above to calculate a dose.
Adverse effects603
Nephrotoxicity — worse than amikacin — Tubular necrosis; usually reversible if stopped early
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Ototoxicity — leans VESTIBULAR (vs amikacin's auditory) — May be irreversible
CatNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Cat · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Neuromuscular blockade — Myasthenia gravis risk
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Side Effects / Adverse Effects table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
These are counts of spontaneously reported events, not proven adverse effects, causal relationships, or incidence rates.
Bars compare report counts within each species; they do not show incidence.
More reportsFewer reportsDog
- Deafness2,101 reports
- Deafness2,043 reports
- Deafness896 reports
- Lack of efficacy - NOS814 reports
- Loss of hearing623 reports
- Vomiting535 reports
- Temporary deafness489 reports
- Temporary deafness486 reports
- Ataxia412 reports
- Head tilt - ear disorder388 reports
- Partial deafness384 reports
- Partial deafness373 reports
Cat
- Ataxia306 reports
- Horner's syndrome174 reports
- Anorexia160 reports
- Head tilt - ear disorder125 reports
- Third eyelid protrusion109 reports
- Anisocoria106 reports
- Nystagmus93 reports
- Vestibular disorder NOS91 reports
- Falling82 reports
- Not eating81 reports
- Behavioural disorder NOS76 reports
- Lethargy (see also Central nervous system depression in 'Neurological')73 reports
Monitoring1
Urine sediment + BUN/creatinine q2–3 days; serum levels if extended therapy (peak/trough); hearing/vestibular watch in cats
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Monitoring Parameters · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Precautions5
Gentamicin assay artifact: beta-lactams falsely lower stored-sample levels — freeze samples, draw at beta-lactam trough.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Same risk set as amikacin: renal disease, neonate/geriatric, dehydration/fever/sepsis, working dogs, sighthounds (reduce dose); rabbits contraindicated
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Contraindications & Warnings table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Gentamicin = vestibular ototoxicity; amikacin = auditory — either can do both, but the exam leans this way. Cats: vestibular sensitivity.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Once-daily dosing logic identical to amikacin (peaks drive kill; low troughs spare the kidney) — exceptions: neutropenia (q8h), renal impairment (extend interval + TDM).
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Brucellosis protocol: gentamicin 5 mg/kg SC q24h weeks 1 & 4 + minocycline (or doxycycline) 25 mg/kg PO q24h × 4 weeks, repeated courses with serologic monitoring.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Clinical pearl · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Interactions5
Loop/osmotic diuretics (furosemide, torsemide, mannitol) — ↑ nephro/ototoxicity
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Other nephrotoxins (amphotericin B, cisplatin, polymyxin B, vancomycin) — Additive renal injury
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Cephalosporins — Possible additive nephrotoxicity (historical, cephaloridine/cephalothin era)
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Beta-lactams — Synergy (Pseudomonas) — separate in vitro mixing; in-vivo inactivation in renal failure
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Neuromuscular blockers/anesthetics — Potentiated blockade
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Drug Interactions table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pharmacokinetics2
Class PK — As amikacin: extracellular distribution, renal elimination unchanged, negligible oral absorption
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Half-life — Short (~1–2 h small animals), prolonged in renal failure
Other speciesNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Other species · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Pharmacokinetics table · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Pregnancy / lactation considerations1
Category C / class C — last resort; fetal ototoxicity possible; milk passage.
Species not recordedNot applicable (NOT_APPLICABLE)1 source record · View provenance
- Species not recorded · Plumb's Veterinary Drug Handbook, 7th ed., p. 567–569; Saunders Handbook of Veterinary Drugs (Papich), 4th ed., p. 353–354 — Pregnancy & Lactation · Not applicable · Not applicable (NOT_APPLICABLE) · Pending clinical review (PROPOSED) · Rule-based
Literature references41
References are linked to this drug. Species applicability is not recorded here, so the species filter does not narrow this list. Imported dates do not retain their original precision; confirm dates in the original citation.
- Immune-pathological response induced by Saprolegnia parasitica in Pangasianodon hypophthalmus and assessment of clinical efficacy of clotrimazole.
Study summary not available in the imported record. Open the original citation to review the study.
- Population pharmacokinetics, in-feed bioavailability and tissue depletion of imidazole antifungal clotrimazole in Pangasianodon hypophthalmus.
Study summary not available in the imported record. Open the original citation to review the study.
- Guava Leaf Extract as a Sustainable Preservative Alternative in Semi-Solid Pharmaceuticals: Efficacy and Stability Assessment.
Study summary not available in the imported record. Open the original citation to review the study.
- Clotrimazole disrupts ergosterol biosynthesis and cell membrane integrity via targeting sterol 14α-demethylases to suppress virulence of Magnaporthe oryzae.
Study summary not available in the imported record. Open the original citation to review the study.
- Hydrophobic drug particles adopt a complex biomolecular corona in ex vivo gastrointestinal fluids.
Study summary not available in the imported record. Open the original citation to review the study.
Sources: PubMed, National Library of Medicine; openFDA, U.S. Food and Drug Administration; Plumb DC. Plumb's Veterinary Drug Handbook. 7th ed. PharmaVet Inc; 2011.