Non-surgical reproduction control

WSAVA guideline

Key findings

• Deslorelin dog ♂: 4.7 mg → ≥6-mo, 9.4 mg → 12-mo infertility (testosterone <0.1 ng/mL ≥180 d); <10 kg >2 yr possible; reversible; off-label BPH (3.1.1.1).
• Deslorelin cats: tom → infertility 6–28 mo; prepubertal queen → puberty +~4 mo; safe surgical alternative in young–adult queens (S6.9).
• Flare-up (bitch): fertile oestrus 1–4 weeks post-implant (even P4 >60 ng/mL); prevented by implanting before 4 mo of age, ≤60 d post-ovulation, ≤7 d post-partum, or after 7 d megestrol; older-bitch off-label use NOT recommended.
• Progestogen hazards: MPA >2.5 mg/kg or >q5-monthly → mammary tumours, CEH, diabetes, acromegaly; megestrol 8-day course → pyometra 0.8%; prolonged high-dose queens → mammary tumours, blindness, CEH/pyometra (3.1.2).
• Mibolerone & melatonin: mibolerone "mg/day" printed — historically µg [verify]; contraindicated in pregnancy, hepatic/renal dysfunction, Bedlington terriers; withdrawn; progestogens preferred in queens. Melatonin: 30 mg PO daily ×35 d (<30 mg ineffective); 18 mg implant best in interoestrus; ineffective in toms (3.1.3–4).
• Immunocontraception: GnRH-KLH → severe injection-site reactions in all dogs; queen 0.5 mL: 93% yr 1 → 27% yr 5; pZP not appropriate (3.2).
• Chemical castration: viable only with 7-day monitoring (S6.9) — not ferals; field zinc-gluconate orchitis 6%; CaCl₂ seepage → scrotal necrosis (3.3).

Drugs named in WSAVA’s own guideline text

As printed in WSAVA’s document, not this app’s own extracted data — see “Related drugs in this reference” below for that.

• Deslorelin implant (Dog ♂ / tom / queen)

  Reversible infertility; BPH

• Megestrol acetate (Bitch / queen)

  Oestrus postponement

• Medroxyprogesterone acetate (Bitch / queen)

  Oestrus postponement

• Mibolerone (Bitch / queen)

  Oestrus postponement

• Methyltestosterone (Bitch)

  Oestrus postponement

• Melatonin (Queen)

  Oestrus postponement

• GnRH-KLH / GnRH-diphtheria toxoid (Dog / cat)

  Immunocontraception

• Calcium chloride (Dog ♂ / tom)

  Chemical castration

• Zinc gluconate (Dog ♂ / tom)

  Chemical castration

• Intra-epididymal agents (Dog / tom)

  Irreversible azoospermia

Recommendations

• Deslorelin: safe surgery-alternative in young–adult queens; temporary infertility in young bitches

  Expert consensus (WSAVA, S6.9)

• NOT recommended: off-label deslorelin for oestrus suppression in older bitches

  Explicit negative recommendation

• Prevent flare-up (timing or megestrol cover); cyproterone 2 mg/kg PO BID ×14 d (behaviour)

  Expert consensus (WSAVA)

• Progestogens > mibolerone in queens; none after medical pyometra; MPA ≤2.5 mg/kg ≥5-monthly

  Expert consensus (WSAVA)

• pZP not appropriate; IUDs NOT recommended; gene therapy experimental

  Expert consensus (WSAVA)

• Intratesticular injection only with 7-day monitoring — not ferals

  Expert consensus (WSAVA)

Related drugs in this reference (0)

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